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10.1021/acsptsci.1c00080

http://scihub22266oqcxt.onion/10.1021/acsptsci.1c00080
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suck abstract from ncbi


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pmid34651104      ACS+Pharmacol+Transl+Sci 2021 ; 4 (5): 1514-1527
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  • Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells #MMPMID34651104
  • Machado RRG; Glaser T; Araujo DB; Petiz LL; Oliveira DBL; Durigon GS; Leal AL; Pinho JRR; Ferreira LCS; Ulrich H; Durigon EL; Guzzo CR
  • ACS Pharmacol Transl Sci 2021[Oct]; 4 (5): 1514-1527 PMID34651104show ga
  • An unprecedented global health crisis has been caused by a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We performed experiments to test if a hypertonic saline solution was capable of inhibiting virus replication. Our data show that 1.2% NaCl inhibited virus replication by 90%, achieving 100% of inhibition at 1.5% in the nonhuman primate kidney cell line Vero, and 1.1% of NaCl was sufficient to inhibit the virus replication by 88% in human epithelial lung cell line Calu-3. Furthermore, our results indicate that the inhibition is due to an intracellular mechanism and not to the dissociation of the spike SARS-CoV-2 protein and its human receptor. NaCl depolarizes the plasma membrane causing a low energy state (high ADP/ATP concentration ratio) without impairing mitochondrial function, supposedly associated with the inhibition of the SARS-CoV-2 life cycle. Membrane depolarization and intracellular energy deprivation are possible mechanisms by which the hypertonic saline solution efficiently prevents virus replication in vitro assays.
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