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10.1155/2021/7880448

http://scihub22266oqcxt.onion/10.1155/2021/7880448
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suck abstract from ncbi


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pmid34651049      Biomed+Res+Int 2021 ; 2021 (ä): 7880448
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  • Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis Signaling #MMPMID34651049
  • Sajdel-Sulkowska EM
  • Biomed Res Int 2021[]; 2021 (ä): 7880448 PMID34651049show ga
  • COVID-19-associated neuropsychiatric complications are soaring. There is an urgent need to understand the link between COVID-19 and neuropsychiatric disorders. To that end, this article addresses the premise that SARS-CoV-2 infection results in gut dysbiosis and an altered microbiota-gut-brain (MGB) axis that in turn contributes to the neuropsychiatric ramifications of COVID-19. Altered MGB axis activity has been implicated independently as a risk of neuropsychiatric disorders. A review of the changes in gut microbiota composition in individual psychiatric and neurological disorders and gut microbiota in COVID-19 patients revealed a shared "microbial signature" characterized by a lower microbial diversity and richness and a decrease in health-promoting anti-inflammatory commensal bacteria accompanied by an increase in opportunistic proinflammatory pathogens. Notably, there was a decrease in short-chain fatty acid (SCFA) producing bacteria. SCFAs are key bioactive microbial metabolites with anti-inflammatory functions and have been recognized as a critical signaling pathway in the MGB axis. SCFA deficiency is associated with brain inflammation, considered a cardinal feature of neuropsychiatric disorders. The link between SARS-CoV-2 infection, gut dysbiosis, and altered MGB axis is further supported by COVID-19-associated gastrointestinal symptoms, a high number of SARS-CoV-2 receptors, angiotensin-cleaving enzyme-2 (ACE-2) in the gut, and viral presence in the fecal matter. The binding of SARS-CoV-2 to the receptor results in ACE-2 deficiency that leads to decreased transport of vital dietary components, gut dysbiosis, proinflammatory gut status, increased permeability of the gut-blood barrier (GBB), and systemic inflammation. More clinical research is needed to substantiate further the linkages described above and evaluate the potential significance of gut microbiota as a diagnostic tool. Meanwhile, it is prudent to propose changes in dietary recommendations in favor of a high fiber diet or supplementation with SCFAs or probiotics to prevent or alleviate the neuropsychiatric ramifications of COVID-19.
  • |Bacteria/metabolism[MESH]
  • |Brain/metabolism/pathology[MESH]
  • |COVID-19/metabolism/microbiology/*psychology/virology[MESH]
  • |Diet[MESH]
  • |Dysbiosis[MESH]
  • |Fatty Acids, Volatile/*metabolism[MESH]
  • |Feces/microbiology[MESH]
  • |Gastrointestinal Diseases/microbiology[MESH]
  • |Gastrointestinal Microbiome/immunology/*physiology[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Probiotics/pharmacology[MESH]


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