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10.1038/s41577-021-00626-8 http://scihub22266oqcxt.onion/10.1038/s41577-021-00626-8 34646033!8511856!34646033     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2022 ; 22 (6): 339-352 Nephropedia Template TP {{tp|p=34646033|t=2022. Lessons in self-defence: inhibition of virus entry by intrinsic immunity |pdf=|usr=}}{{34646033}} gab.com Text Lessons in self-defence: inhibition of virus entry by intrinsic immunity JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34646033 #FOAvip Virus entry, consisting of attachment to and penetration into the host target cell, is the first step of the virus life cycle and is a critical 'do or die' event that governs virus emergence in host populations. Most antiviral vaccines induce neutralizing antibodies that prevent virus entry into cells. However, while the prevention of virus invasion by humoral immunity is well appreciated, considerably less is known about the immune defences present within cells (known as intrinsic immunity) that interfere with virus entry. The interferon-induced transmembrane (IFITM) proteins, known for inhibiting fusion between viral and cellular membranes, were once the only factors known to restrict virus entry. However, the progressive development of genetic and pharmacological screening platforms and the onset of the COVID-19 pandemic have galvanized interest in how viruses infiltrate cells and how cells defend against it. Several host factors with antiviral potential are now implicated in the regulation of virus entry, including cholesterol 25-hydroxylase (CH25H), lymphocyte antigen 6E (LY6E), nuclear receptor co-activator protein 7 (NCOA7), interferon-gamma-inducible lysosomal thiol reductase (GILT), CD74 and ARFGAP with dual pleckstrin homology domain-containing protein 2 (ADAP2). This Review summarizes what is known and what remains to be understood about the intrinsic factors that form the first line of defence against virus infection. Twit Text FOAVip Lessons in self-defence: inhibition of virus entry by intrinsic immunity ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34646033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34646033 #FOAvip English Wikipedia <ref>{{Cite pmid|34646033}}</ref> Lessons in self-defence: inhibition of virus entry by intrinsic immunity #MMPMID34646033 Majdoul S; Compton AA Nat Rev Immunol 2022[Jun]; 22 (6): 339-352 PMID34646033show ga Virus entry, consisting of attachment to and penetration into the host target cell, is the first step of the virus life cycle and is a critical 'do or die' event that governs virus emergence in host populations. Most antiviral vaccines induce neutralizing antibodies that prevent virus entry into cells. However, while the prevention of virus invasion by humoral immunity is well appreciated, considerably less is known about the immune defences present within cells (known as intrinsic immunity) that interfere with virus entry. The interferon-induced transmembrane (IFITM) proteins, known for inhibiting fusion between viral and cellular membranes, were once the only factors known to restrict virus entry. However, the progressive development of genetic and pharmacological screening platforms and the onset of the COVID-19 pandemic have galvanized interest in how viruses infiltrate cells and how cells defend against it. Several host factors with antiviral potential are now implicated in the regulation of virus entry, including cholesterol 25-hydroxylase (CH25H), lymphocyte antigen 6E (LY6E), nuclear receptor co-activator protein 7 (NCOA7), interferon-gamma-inducible lysosomal thiol reductase (GILT), CD74 and ARFGAP with dual pleckstrin homology domain-containing protein 2 (ADAP2). This Review summarizes what is known and what remains to be understood about the intrinsic factors that form the first line of defence against virus infection. |*COVID-19[MESH] |*Virus Internalization[MESH] |Antiviral Agents[MESH] |Humans[MESH] |Interferons[MESH] |Membrane Proteins/metabolism[MESH]Lessons in self-defence: inhibition of virus entry by intrinsic immuni(epmc).pdf DeepDyve Pubget Overpricing