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10.1128/Spectrum.00055-21

http://scihub22266oqcxt.onion/10.1128/Spectrum.00055-21
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34643448!8515944!34643448
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suck abstract from ncbi


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pmid34643448      Microbiol+Spectr 2021 ; 9 (2): e0005521
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  • Oral Microbiome Alterations and SARS-CoV-2 Saliva Viral Load in Patients with COVID-19 #MMPMID34643448
  • Miller EH; Annavajhala MK; Chong AM; Park H; Nobel YR; Soroush A; Blackett JW; Krigel A; Phipps MM; Freedberg DE; Zucker J; Sano ED; Uhlemann AC; Abrams JA
  • Microbiol Spectr 2021[Oct]; 9 (2): e0005521 PMID34643448show ga
  • Bacterial-viral interactions in saliva have been associated with morbidity and mortality for respiratory viruses such as influenza and SARS-CoV. However, such transkingdom relationships during SARS-CoV-2 infection are currently unknown. Here, we aimed to elucidate the relationship between saliva microbiota and SARS-CoV-2 in a cohort of newly hospitalized COVID-19 patients and controls. We used 16S rRNA sequencing to compare microbiome diversity and taxonomic composition between COVID-19 patients (n = 53) and controls (n = 59) and based on saliva SARS-CoV-2 viral load as measured using reverse transcription PCR (RT-PCR). The saliva microbiome did not differ markedly between COVID-19 patients and controls. However, we identified significant differential abundance of numerous taxa based on saliva SARS-CoV-2 viral load, including multiple species within Streptococcus and Prevotella. IMPORTANCE Alterations to the saliva microbiome based on SARS-CoV-2 viral load indicate potential biologically relevant bacterial-viral relationships which may affect clinical outcomes in COVID-19 disease.
  • |Bacteria/*classification/genetics[MESH]
  • |COVID-19/*pathology[MESH]
  • |Dysbiosis/microbiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Microbial Interactions/*physiology[MESH]
  • |Microbiota/genetics[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/microbiology[MESH]
  • |RNA, Ribosomal, 16S/genetics[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]
  • |Saliva/*microbiology[MESH]


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