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10.1002/ptr.7302

http://scihub22266oqcxt.onion/10.1002/ptr.7302
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suck abstract from ncbi


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pmid34643000      Phytother+Res 2021 ; 35 (12): 6893-6903
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  • Cannabidiol inhibits SARS-Cov-2 spike (S) protein-induced cytotoxicity and inflammation through a PPARgamma-dependent TLR4/NLRP3/Caspase-1 signaling suppression in Caco-2 cell line #MMPMID34643000
  • Corpetti C; Del Re A; Seguella L; Palenca I; Rurgo S; De Conno B; Pesce M; Sarnelli G; Esposito G
  • Phytother Res 2021[Dec]; 35 (12): 6893-6903 PMID34643000show ga
  • Given the abundancy of angiotensin converting enzyme 2 (ACE-2) receptors density, beyond the lung, the intestine is considered as an alternative site of infection and replication for severe acute respiratory syndrome by coronavirus type 2 (SARS-CoV-2). Cannabidiol (CBD) has recently been proposed in the management of coronavirus disease 2019 (COVID-19) respiratory symptoms because of its anti-inflammatory and immunomodulatory activity exerted in the lung. In this study, we demonstrated the in vitro PPAR-gamma-dependent efficacy of CBD (10(-9) -10(-7) M) in preventing epithelial damage and hyperinflammatory response triggered by SARS-CoV-2 spike protein (SP) in a Caco-2 cells. Immunoblot analysis revealed that CBD was able to reduce all the analyzed proinflammatory markers triggered by SP incubation, such as tool-like receptor 4 (TLR-4), ACE-2, family members of Ras homologues A-GTPase (RhoA-GTPase), inflammasome complex (NLRP3), and Caspase-1. CBD caused a parallel inhibition of interleukin 1 beta (IL-1beta), IL-6, tumor necrosis factor alpha (TNF-alpha), and IL-18 by enzyme-linked immunosorbent assay (ELISA) assay. By immunofluorescence analysis, we observed increased expression of tight-junction proteins and restoration of transepithelial electrical resistance (TEER) following CBD treatment, as well as the rescue of fluorescein isothiocyanate (FITC)-dextran permeability induced by SP. Our data indicate, in conclusion, that CBD is a powerful inhibitor of SP protein enterotoxicity in vitro.
  • |*Cannabidiol/pharmacology[MESH]
  • |COVID-19[MESH]
  • |Caco-2 Cells[MESH]
  • |Caspase 1[MESH]
  • |Cytokines[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |NLR Family, Pyrin Domain-Containing 3 Protein[MESH]
  • |PPAR gamma[MESH]
  • |SARS-CoV-2/*drug effects[MESH]
  • |Signal Transduction/*drug effects[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]


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