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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Med 2021 ; 10 (19): ä Nephropedia Template TP
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Correlation between alpha1-Antitrypsin Deficiency and SARS-CoV-2 Infection: Epidemiological Data and Pathogenetic Hypotheses #MMPMID34640510
Vianello A; Guarnieri G; Braccioni F; Molena B; Lococo S; Achille A; Lionello F; Salviati L; Caminati M; Senna G
J Clin Med 2021[Sep]; 10 (19): ä PMID34640510show ga
The most common hereditary disorder in adults, alpha1-antitrypsin deficiency (AATD), is characterized by reduced plasma levels or the abnormal functioning of alpha1-antitrypsin (AAT), a major human blood serine protease inhibitor, which is encoded by the SERine Protein INhibitor-A1 (SERPINA1) gene and produced in the liver. Recently, it has been hypothesized that the geographic differences in COVID-19 infection and fatality rates may be partially explained by ethnic differences in SERPINA1 allele frequencies. In our review, we examined epidemiological data on the correlation between the distribution of AATD, SARS-CoV-2 infection, and COVID-19 mortality rates. Moreover, we described shared pathogenetic pathways that may provide a theoretical basis for our epidemiological findings. We also considered the potential use of AAT augmentation therapy in patients with COVID-19.