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10.3390/ijms221910730 http://scihub22266oqcxt.onion/10.3390/ijms221910730 34639073!8509397!34639073     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (19): ä Nephropedia Template TP {{tp|p=34639073|t=2021. Molecular Mechanism of the Anti-Inflammatory Action of Heparin |pdf=|usr=}}{{34639073}} gab.com Text Molecular Mechanism of the Anti-Inflammatory Action of Heparin JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34639073 #FOAvip Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. The mechanism of heparin binding to IFNgamma and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. The effect of LMWH on IFNgamma signalling inside stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. We found that LMWH binds with high affinity to IFNgamma and is able to fully inhibit the interaction with its cellular receptor. It also influences the biological activity of IL-6 by binding to either IL-6 or IL-6/IL-6Ralpha, thus preventing the formation of the IL-6/IL-6Ralpha/gp130 signalling complex. These findings shed light on the molecular mechanism of the anti-inflammatory action of LMWH and underpin its ability to influence favourably conditions characterised by overexpression of these two cytokines. Such conditions are not only associated with autoimmune diseases, but also with inflammatory processes, in particular with COVID-19. Our results put forward heparin as a promising means for the prevention and suppression of severe CRS and encourage further investigations on its applicability as an anti-inflammatory agent. Twit Text FOAVip Molecular Mechanism of the Anti-Inflammatory Action of Heparin ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34639073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34639073 #FOAvip English Wikipedia <ref>{{Cite pmid|34639073}}</ref> Molecular Mechanism of the Anti-Inflammatory Action of Heparin #MMPMID34639073 Litov L; Petkov P; Rangelov M; Ilieva N; Lilkova E; Todorova N; Krachmarova E; Malinova K; Gospodinov A; Hristova R; Ivanov I; Nacheva G Int J Mol Sci 2021[Oct]; 22 (19): ä PMID34639073show ga Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. The mechanism of heparin binding to IFNgamma and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. The effect of LMWH on IFNgamma signalling inside stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. We found that LMWH binds with high affinity to IFNgamma and is able to fully inhibit the interaction with its cellular receptor. It also influences the biological activity of IL-6 by binding to either IL-6 or IL-6/IL-6Ralpha, thus preventing the formation of the IL-6/IL-6Ralpha/gp130 signalling complex. These findings shed light on the molecular mechanism of the anti-inflammatory action of LMWH and underpin its ability to influence favourably conditions characterised by overexpression of these two cytokines. Such conditions are not only associated with autoimmune diseases, but also with inflammatory processes, in particular with COVID-19. Our results put forward heparin as a promising means for the prevention and suppression of severe CRS and encourage further investigations on its applicability as an anti-inflammatory agent. |Anti-Inflammatory Agents/*pharmacology[MESH] |Anticoagulants/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/immunology[MESH] |Cell Line[MESH] |Heparin, Low-Molecular-Weight/*pharmacology[MESH] |Humans[MESH] |Interferon-gamma/*immunology[MESH] |Interleukin-6/*immunology[MESH] |Models, Molecular[MESH] |Receptors, Interleukin-6/immunology[MESH]Molecular Mechanism of the Anti-Inflammatory Action of Heparin (epmc).pdf DeepDyve Pubget Overpricing