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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Rev+Alerg+Mex 2021 ; 68 (3): 185-197 Nephropedia Template TP
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Participacion de la vitamina A en la produccion de IgA secretora en el epitelio del tracto respiratorio para la potencial proteccion de infeccion por SARS-CoV-2 #MMPMID34634849
Rev Alerg Mex 2021[Jul]; 68 (3): 185-197 PMID34634849show ga
SARS-CoV-2 continues to infect thousands of people around the world. It has been established that the main transmission mechanism of this virus is via airborne route, which is why it initially infects the respiratory tract. Currently, the effectiveness of medications used against COVID-19 is limited, and although immunization programs have been initiated, there is international inequality in the distribution of vaccines. Accordingly, the search for adjuvant therapies continues to be an alternative for research. Supplementation with vitamin A has been associated to the decrease of mortality from infection; this effect could be mediated by retinoic acid (RA), which is the active metabolite of vitamin A that exerts immunomodulatory functions. According to preclinical studies, RA favors the production of secretory immunoglobulin A (IgA) in the respiratory tract. In addition to this, the retinol-binding protein has been correlated with the concentration of IgA and neutralizing antibodies in patients with influenza. Therefore, this review aims to address the involvement of vitamin A in the production of secretory IgA in the respiratory epithelium in order to highlight its potential protection against SARS-CoV-2 infection.