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10.1093/nar/gkab881

http://scihub22266oqcxt.onion/10.1093/nar/gkab881
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suck abstract from ncbi


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pmid34634820      Nucleic+Acids+Res 2022 ; 50 (D1): D867-D874
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  • SCovid: single-cell atlases for exposing molecular characteristics of COVID-19 across 10 human tissues #MMPMID34634820
  • Qi C; Wang C; Zhao L; Zhu Z; Wang P; Zhang S; Cheng L; Zhang X
  • Nucleic Acids Res 2022[Jan]; 50 (D1): D867-D874 PMID34634820show ga
  • SCovid (http://bio-annotation.cn/scovid) aims at providing a comprehensive resource of single-cell data for exposing molecular characteristics of coronavirus disease 2019 (COVID-19) across 10 human tissues. COVID-19, an epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been found to be accompanied with multiple-organ failure since its first report in Dec 2019. To reveal tissue-specific molecular characteristics, researches regarding to COVID-19 have been carried out widely, especially at single-cell resolution. However, these researches are still relatively independent and scattered, limiting the comprehensive understanding of the impact of virus on diverse tissues. To this end, we developed a single-cell atlas of COVID-19. Firstly we collected 21 single-cell datasets of COVID-19 across 10 human tissues paired with control datasets. Then we constructed a pipeline for the analysis of these datasets to reveal molecular characteristics of COVID-19 based on manually annotated cell types. The current version of SCovid documents 1 042 227 single cells of 21 single-cell datasets across 10 human tissues, 11 713 stably expressed genes and 3778 significant differentially expressed genes (DEGs). SCovid provides a user-friendly interface for browsing, searching, visualizing and downloading all detailed information.
  • |*Databases, Factual[MESH]
  • |*Single-Cell Analysis[MESH]
  • |COVID-19/genetics/*pathology[MESH]
  • |Humans[MESH]
  • |Transcriptome[MESH]


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