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10.1080/14787210.2022.1990756 http://scihub22266oqcxt.onion/10.1080/14787210.2022.1990756 34633277!8544661!34633277     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Rev+Anti+Infect+Ther 2022 ; 20 (3): 383-390 Nephropedia Template TP {{tp|p=34633277|t=2022. Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19 |pdf=|usr=}}{{34633277}} gab.com Text Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19 JO: Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=34633277 #FOAvip INTRODUCTION: COVID-19, a dreadful pandemic that has impacted human life like no other pathogenic invasion, has claimed the lives of over 100 million people. The need for effective treatment strategies is still a subject of intense research considering the rapidly evolving genome and continental diversity. Indomethacin is administered mostly as co-treatment for affected patients as a non-steroidal anti-inflammatory drug (NSAID). However, the underlying mechanism of action is unresolved. This study explores the basal mechanism of indomethacin and potency in alleviating the damage caused by SARS-CoV-2 and discusses the experimental and clinical efficacy in recent studies. AREAS COVERED: The literature search and system biology-based network formation were employed to describe the potent effects and risks associated with indomethacin in in-vitro, in-vivo, and clinical studies. This study also highlights the plausible mechanism of antiviral action of indomethacin with its apparent viral protein targets. The SARS-CoV-2 protein, the interacting host proteins, and the effect of indomethacin on this interactome as a standalone treatment or as part of a co-therapy strategy are particularly emphasized using network modeling. EXPERT OPINION: Indomethacin has demonstrated excellent clinical endpoint characteristics in several studies, and we recommend that it be utilized in the treatment of mild-to-moderate COVID patients. Twit Text FOAVip Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19 ????Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=34633277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34633277 #FOAvip English Wikipedia <ref>{{Cite pmid|34633277}}</ref> Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19 #MMPMID34633277 Shekhar N; Kaur H; Sarma P; Prakash A; Medhi B Expert Rev Anti Infect Ther 2022[Mar]; 20 (3): 383-390 PMID34633277show ga INTRODUCTION: COVID-19, a dreadful pandemic that has impacted human life like no other pathogenic invasion, has claimed the lives of over 100 million people. The need for effective treatment strategies is still a subject of intense research considering the rapidly evolving genome and continental diversity. Indomethacin is administered mostly as co-treatment for affected patients as a non-steroidal anti-inflammatory drug (NSAID). However, the underlying mechanism of action is unresolved. This study explores the basal mechanism of indomethacin and potency in alleviating the damage caused by SARS-CoV-2 and discusses the experimental and clinical efficacy in recent studies. AREAS COVERED: The literature search and system biology-based network formation were employed to describe the potent effects and risks associated with indomethacin in in-vitro, in-vivo, and clinical studies. This study also highlights the plausible mechanism of antiviral action of indomethacin with its apparent viral protein targets. The SARS-CoV-2 protein, the interacting host proteins, and the effect of indomethacin on this interactome as a standalone treatment or as part of a co-therapy strategy are particularly emphasized using network modeling. EXPERT OPINION: Indomethacin has demonstrated excellent clinical endpoint characteristics in several studies, and we recommend that it be utilized in the treatment of mild-to-moderate COVID patients. |*Antiviral Agents/pharmacology/therapeutic use[MESH] |*COVID-19 Drug Treatment[MESH] |*Host-Pathogen Interactions[MESH] |*Indomethacin/pharmacology/therapeutic use[MESH] |Humans[MESH]Indomethacin: an exploratory study of antiviral mechanism and host-pat(epmc).pdf DeepDyve Pubget Overpricing