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10.1080/19490976.2021.1984105 http://scihub22266oqcxt.onion/10.1080/19490976.2021.1984105 34632957!8510562!34632957     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gut+Microbes 2021 ; 13 (1): 1984105 Nephropedia Template TP {{tp|p=34632957|t=2021. Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiota |pdf=|usr=}}{{34632957}} gab.com Text Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiota JO: Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=34632957 #FOAvip Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (Ace2) is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic Ace2 expression using a humanized mouse model. We found that colonic Ace2 expression decreased significantly upon microbial colonization. Humanization with healthy volunteer or dysbiotic microbiota from irritable bowel syndrome (IBS) patients resulted in similar Ace2 expression. Despite the differences in microbiota, no associations between alpha-diversity, beta-diversity or individual taxa, and Ace2 were noted post-humanization. These results highlight that commensal microbiota play a key role in regulating intestinal Ace2 expression and the need to further examine the underlying mechanisms of this regulation. Twit Text FOAVip Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiota ????Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=34632957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34632957 #FOAvip English Wikipedia <ref>{{Cite pmid|34632957}}</ref> Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiota #MMPMID34632957 Edwinson A; Yang L; Chen J; Grover M Gut Microbes 2021[Jan]; 13 (1): 1984105 PMID34632957show ga Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (Ace2) is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic Ace2 expression using a humanized mouse model. We found that colonic Ace2 expression decreased significantly upon microbial colonization. Humanization with healthy volunteer or dysbiotic microbiota from irritable bowel syndrome (IBS) patients resulted in similar Ace2 expression. Despite the differences in microbiota, no associations between alpha-diversity, beta-diversity or individual taxa, and Ace2 were noted post-humanization. These results highlight that commensal microbiota play a key role in regulating intestinal Ace2 expression and the need to further examine the underlying mechanisms of this regulation. |*Gastrointestinal Microbiome[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |Colon/*metabolism/microbiology[MESH] |Dysbiosis[MESH] |Gene Expression Regulation[MESH] |Germ-Free Life[MESH] |Humans[MESH] |Inflammatory Bowel Diseases/microbiology[MESH] |Mice[MESH] |Receptors, Virus/metabolism[MESH]Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppress(epmc).pdf DeepDyve Pubget Overpricing