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10.1111/bph.15670 http://scihub22266oqcxt.onion/10.1111/bph.15670 34632567!8653109!34632567     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2022 ; 179 (10): 2081-2085 Nephropedia Template TP {{tp|p=34632567|t=2022. Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapies |pdf=|usr=}}{{34632567}} gab.com Text Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapies JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34632567 #FOAvip Pyroptosis is a specialized form of inflammatory cell death which aids the defensive response against invading pathogens. Its normally tight regulation is lost during infection by the severe acute respiratory coronavirus 2 (SARS-CoV-2), and thus, uncontrolled pyroptosis disrupts the immune system and the integrity of organs defining the critical conditions in patients with high viral load. Molecular pathways engaged downstream of the formation and stabilization of the inflammasome, which are necessary to execute the process, have been uncovered and drugs are available for their regulation. However, the pharmacology of the upstream events, which are critical to sense and interpret the initial damage by the pathogen, is far from being elucidated. This limits our capacity to identify early markers and targets to ameliorate SARS-CoV-2 linked pyroptosis. Here, we focus attention on the mitochondria and pathways leading to their dysfunction, in order to elucidate the early steps of inflammasome formation and devise tools to predict and counter pathological states induced by SARS-CoV-2. LINKED ARTICLES: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc. Twit Text FOAVip Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapies ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34632567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34632567 #FOAvip English Wikipedia <ref>{{Cite pmid|34632567}}</ref> Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapies #MMPMID34632567 Singh A; Strobbe D; Campanella M Br J Pharmacol 2022[May]; 179 (10): 2081-2085 PMID34632567show ga Pyroptosis is a specialized form of inflammatory cell death which aids the defensive response against invading pathogens. Its normally tight regulation is lost during infection by the severe acute respiratory coronavirus 2 (SARS-CoV-2), and thus, uncontrolled pyroptosis disrupts the immune system and the integrity of organs defining the critical conditions in patients with high viral load. Molecular pathways engaged downstream of the formation and stabilization of the inflammasome, which are necessary to execute the process, have been uncovered and drugs are available for their regulation. However, the pharmacology of the upstream events, which are critical to sense and interpret the initial damage by the pathogen, is far from being elucidated. This limits our capacity to identify early markers and targets to ameliorate SARS-CoV-2 linked pyroptosis. Here, we focus attention on the mitochondria and pathways leading to their dysfunction, in order to elucidate the early steps of inflammasome formation and devise tools to predict and counter pathological states induced by SARS-CoV-2. LINKED ARTICLES: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc. |*COVID-19 Drug Treatment[MESH] |Humans[MESH] |Inflammasomes[MESH] |Mitochondria[MESH] |Pyroptosis[MESH]Pyroptosis targeting via mitochondria: An educated guess to innovate C(epmc).pdf DeepDyve Pubget Overpricing