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10.3389/fimmu.2021.753558

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.753558
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34630432!8492986!34630432
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suck abstract from ncbi


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pmid34630432      Front+Immunol 2021 ; 12 (ä): 753558
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  • Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report #MMPMID34630432
  • Sherwood KR; Nicholl DDM; Fenninger F; Wu V; Wong P; Benedicto V; Cina DP; Wang M; Pobran TD; De Marco ML; Marquez AC; Jassem AN; Sekirov I; Morshed MG; Bardi M; Sekhon M; Keown P; Kadatz M; Lan JH
  • Front Immunol 2021[]; 12 (ä): 753558 PMID34630432show ga
  • To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient's transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host's ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.
  • |*Kidney Transplantation[MESH]
  • |Adult[MESH]
  • |Basiliximab/*therapeutic use[MESH]
  • |COVID-19/*immunology[MESH]
  • |Glomerulonephritis, IGA/*therapy[MESH]
  • |Graft Rejection/*immunology[MESH]
  • |Humans[MESH]
  • |Immune Tolerance[MESH]
  • |Immunity[MESH]
  • |Immunosuppressive Agents/*therapeutic use[MESH]
  • |Male[MESH]
  • |Perioperative Period[MESH]
  • |SARS-CoV-2/*physiology[MESH]


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