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10.3389/fimmu.2021.748566 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.748566 34630427!8495247!34630427     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 748566 Nephropedia Template TP {{tp|p=34630427|t=2021. Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study |pdf=|usr=}}{{34630427}} gab.com Text Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34630427 #FOAvip Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection. Twit Text FOAVip Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34630427 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34630427 #FOAvip English Wikipedia <ref>{{Cite pmid|34630427}}</ref> Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study #MMPMID34630427 Hou H; Yang H; Liu P; Huang C; Wang M; Li Y; Zhu M; Wang J; Xu Y; Wang Y; Ma Q; Li D; Liao P; Wang W Front Immunol 2021[]; 12 (ä): 748566 PMID34630427show ga Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection. |Adult[MESH] |Antibody-Dependent Cell Cytotoxicity[MESH] |COVID-19/*metabolism[MESH] |Case-Control Studies[MESH] |Chromatography, High Pressure Liquid[MESH] |Complement Pathway, Mannose-Binding Lectin[MESH] |Female[MESH] |Glycosylation[MESH] |Humans[MESH] |Immunoglobulin G/*metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Phenotype[MESH]Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Con(epmc).pdf DeepDyve Pubget Overpricing