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10.1016/j.it.2021.09.003 http://scihub22266oqcxt.onion/10.1016/j.it.2021.09.003 34629295!8496891!34629295     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34629295&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Trends+Immunol 2021 ; 42 (11): 1009-1023 Nephropedia Template TP {{tp|p=34629295|t=2021. Differential roles of interferons in innate responses to mucosal viral infections |pdf=|usr=}}{{34629295}} gab.com Text Differential roles of interferons in innate responses to mucosal viral infections JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34629295 #FOAvip Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. Inhibition of viral establishment and spread at and from these mucosal sites is paramount for preventing severe disease, while concomitantly limiting putative detrimental effects of inflammation. Here, we compare the roles of type I, II, and III IFNs in regulating three archetypal viruses - norovirus, herpes simplex virus, and severe acute respiratory virus coronavirus 2 (SARS-CoV-2) - which infect distinct mammalian mucosal tissues. Emerging paradigms include highly specific roles for IFNs in limiting local versus systemic infection, synergistic activities, and a spectrum of protective versus detrimental effects of IFNs during the infection response. Twit Text FOAVip Differential roles of interferons in innate responses to mucosal viral infections ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34629295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34629295 #FOAvip English Wikipedia <ref>{{Cite pmid|34629295}}</ref> Differential roles of interferons in innate responses to mucosal viral infections #MMPMID34629295 Walker FC; Sridhar PR; Baldridge MT Trends Immunol 2021[Nov]; 42 (11): 1009-1023 PMID34629295show ga Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. Inhibition of viral establishment and spread at and from these mucosal sites is paramount for preventing severe disease, while concomitantly limiting putative detrimental effects of inflammation. Here, we compare the roles of type I, II, and III IFNs in regulating three archetypal viruses - norovirus, herpes simplex virus, and severe acute respiratory virus coronavirus 2 (SARS-CoV-2) - which infect distinct mammalian mucosal tissues. Emerging paradigms include highly specific roles for IFNs in limiting local versus systemic infection, synergistic activities, and a spectrum of protective versus detrimental effects of IFNs during the infection response. |*COVID-19[MESH] |*Virus Diseases[MESH] |Animals[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferons[MESH] |Mucous Membrane[MESH] |SARS-CoV-2[MESH]Differential roles of interferons in innate responses to mucosal viral(epmc).pdf DeepDyve Pubget Overpricing