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  • Activation of STAT3 signaling pathway in the kidney of COVID-19 patients #MMPMID34626364
  • Salem F; Li XZ; Hindi J; Casablanca NM; Zhong F; El Jamal SM; Haroon Al Rasheed MR; Li L; Lee K; Chan L; He JC
  • J Nephrol 2022[Apr]; 35 (3): 735-743 PMID34626364show ga
  • BACKGROUND: Acute kidney injury is common in patients with COVID-19, however mechanisms of kidney injury remain unclear. Since cytokine storm is likely a cause of AKI and glomerular disease, we investigated the two major transcription factors, STAT3 and NF-kB, which are known to be activated by cytokines. METHODS: This is an observational study of the postmortem kidneys of 50 patients who died with COVID-19 in the Mount Sinai Hospital during the first pandemic surge. All samples were reviewed under light microscopy, electron microscopy, and immunofluorescence by trained renal pathologists. In situ hybridization evaluation for SARS-CoV-2 and immunostaining of transcription factors STAT3 and NF-kB were performed. RESULTS: Consistent with previous findings, acute tubular injury was the major pathological finding, together with global or focal glomerulosclerosis. We were not able to detect SARS-CoV-2 in kidney cells. ACE2 expression was reduced in the tubular cells of patients who died with COVID-19 and did not co-localize with TMPRSS2. SARS-CoV-2 was identified occasionally in the mononuclear cells in the peritubular capillary and interstitium. STAT3 phosphorylation at Tyr705 was increased in 2 cases in the glomeruli and in 3 cases in the tubulointerstitial compartments. Interestingly, STAT3 phosphorylation at Ser727 increased in 9 cases but only in the tubulointerstitial compartment. A significant increase in NF-kB phosphorylation at Ser276 was also found in the tubulointerstitium of the two patients with increased p-STAT3 (Tyr705). CONCLUSIONS: Our findings suggest that, instead of tyrosine phosphorylation, serine phosphorylation of STAT3 is commonly activated in the kidney of patients with COVID-19.
  • |*Acute Kidney Injury/diagnosis/pathology[MESH]
  • |*COVID-19/complications[MESH]
  • |Humans[MESH]
  • |Kidney/pathology[MESH]
  • |NF-kappa B[MESH]
  • |SARS-CoV-2[MESH]
  • |STAT3 Transcription Factor[MESH]
  • |Signal Transduction[MESH]

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  • suck abstract from ncbi

    735 3.35 2022