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10.1016/j.jneuroim.2021.577728

http://scihub22266oqcxt.onion/10.1016/j.jneuroim.2021.577728
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suck abstract from ncbi


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pmid34619427      J+Neuroimmunol 2021 ; 361 (ä): 577728
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  • The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases #MMPMID34619427
  • Cama VF; Marin-Prida J; Acosta-Rivero N; Acosta EF; Diaz LO; Casadesus AV; Fernandez-Marrero B; Gilva-Rodriguez N; Cremata-Garcia D; Cervantes-Llanos M; Piniella-Matamoros B; Sanchez D; Del Rosario-Cruz L; Borrajero I; Diaz A; Gonzalez Y; Penton-Arias E; Montero-Gonzalez T; Guillen-Nieto G; Penton-Rol G
  • J Neuroimmunol 2021[Dec]; 361 (ä): 577728 PMID34619427show ga
  • We herein report, by using confocal immunofluorescence, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and microglia in three deceased COVID-19 cases, of between 78 and 85 years of age at death. The viral nucleocapsid was detected together with its ACE2 cell entry receptor, as well as the NLRP3 inflammasome in cerebral cortical tissues. It is noteworthy that NLRP3 was colocalized with CD68 + macrophages in the brain and lung of the deceased, suggesting the critical role of this type of inflammasome in SARS-CoV-2 lesions of the nervous system/lungs and supporting its potential role as a therapeutic target.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Astrocytes/virology[MESH]
  • |Autopsy[MESH]
  • |Brain/immunology/pathology/*virology[MESH]
  • |COVID-19/immunology/pathology/*virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammasomes/*immunology[MESH]
  • |Male[MESH]
  • |Microglia/immunology/*virology[MESH]
  • |NLR Family, Pyrin Domain-Containing 3 Protein/*immunology[MESH]
  • |Neurons/virology[MESH]
  • |Nucleocapsid[MESH]
  • |Oligodendroglia/virology[MESH]


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