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10.1126/sciimmunol.abl9105 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abl9105 34618554!8626868!34618554     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (65): eabl9105 Nephropedia Template TP {{tp|p=34618554|t=2021. SARS-CoV-2 infection generates tissue-localized immunological memory in humans |pdf=|usr=}}{{34618554}} gab.com Text SARS-CoV-2 infection generates tissue-localized immunological memory in humans JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34618554 #FOAvip Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4(+) T, CD8(+) T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months after infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2-specific memory T and B cells with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2-specific germinal centers in the lung-associated LNs up to 6 months after infection. SARS-CoV-2-specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges. Twit Text FOAVip SARS-CoV-2 infection generates tissue-localized immunological memory in humans ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34618554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34618554 #FOAvip English Wikipedia <ref>{{Cite pmid|34618554}}</ref> SARS-CoV-2 infection generates tissue-localized immunological memory in humans #MMPMID34618554 Poon MML; Rybkina K; Kato Y; Kubota M; Matsumoto R; Bloom NI; Zhang Z; Hastie KM; Grifoni A; Weiskopf D; Wells SB; Ural BB; Lam N; Szabo PA; Dogra P; Lee YS; Gray JI; Bradley MC; Brusko MA; Brusko TM; Saphire EO; Connors TJ; Sette A; Crotty S; Farber DL Sci Immunol 2021[Nov]; 6 (65): eabl9105 PMID34618554show ga Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4(+) T, CD8(+) T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months after infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2-specific memory T and B cells with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2-specific germinal centers in the lung-associated LNs up to 6 months after infection. SARS-CoV-2-specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges. |*Immunity, Cellular[MESH] |*Immunologic Memory[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Humans[MESH] |Lymphocytes/*immunology[MESH] |Male[MESH] |Organ Specificity/immunology[MESH]SARS-CoV-2 infection generates tissue-localized immunological memory i(epmc).pdf DeepDyve Pubget Overpricing