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10.1038/s41598-021-99344-3 http://scihub22266oqcxt.onion/10.1038/s41598-021-99344-3 34615949!8494911!34615949     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 19817 Nephropedia Template TP {{tp|p=34615949|t=2021. Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients |pdf=|usr=}}{{34615949}} gab.com Text Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34615949 #FOAvip Recent studies have focused their attention on conjunctivitis as one of the symptoms of coronavirus disease 2019 (COVID-19). Therefore, tear samples were taken from COVID-19 patients and the presence of SARS-CoV-2 was evidenced using Real Time reverse transcription polymerase chain reaction. The main aim of this study was to analyze mRNA expression in the tears of patients with COVID-19 compared with healthy subjects using Next Generation Sequencing (NGS). The functional evaluation of the transcriptome highlighted 25 genes that differ statistically between healthy individuals and patients affected by COVID-19. In particular, the NGS analysis identified the presence of several genes involved in B cell signaling and keratinization. In particular, the genes involved in B cell signaling were downregulated in the tears of COVID-19 patients, while those involved in keratinization were upregulated. The results indicated that SARS-CoV-2 may induce a process of ocular keratinization and a defective B cell response. Twit Text FOAVip Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34615949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34615949 #FOAvip English Wikipedia <ref>{{Cite pmid|34615949}}</ref> Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients #MMPMID34615949 Mastropasqua L; Toto L; Chiricosta L; Diomede F; Gugliandolo A; Silvestro S; Marconi GD; Sinjari B; Vecchiet J; Cipollone F; D'Ardes D; Auricchio A; Lanzini M; Caputi S; D'Aloisio R; Mazzon E; Trubiani O Sci Rep 2021[Oct]; 11 (1): 19817 PMID34615949show ga Recent studies have focused their attention on conjunctivitis as one of the symptoms of coronavirus disease 2019 (COVID-19). Therefore, tear samples were taken from COVID-19 patients and the presence of SARS-CoV-2 was evidenced using Real Time reverse transcription polymerase chain reaction. The main aim of this study was to analyze mRNA expression in the tears of patients with COVID-19 compared with healthy subjects using Next Generation Sequencing (NGS). The functional evaluation of the transcriptome highlighted 25 genes that differ statistically between healthy individuals and patients affected by COVID-19. In particular, the NGS analysis identified the presence of several genes involved in B cell signaling and keratinization. In particular, the genes involved in B cell signaling were downregulated in the tears of COVID-19 patients, while those involved in keratinization were upregulated. The results indicated that SARS-CoV-2 may induce a process of ocular keratinization and a defective B cell response. |*Transcriptome[MESH] |Aged[MESH] |B-Lymphocytes/metabolism[MESH] |COVID-19/*genetics/pathology/virology[MESH] |Eye Diseases/genetics/*virology[MESH] |Female[MESH] |High-Throughput Nucleotide Sequencing/methods[MESH] |Humans[MESH] |Keratins/metabolism[MESH] |Male[MESH] |SARS-CoV-2/isolation & purification[MESH] |Sequence Analysis, RNA/methods[MESH] |Skin/metabolism/pathology/virology[MESH]Transcriptomic analysis revealed increased expression of genes involve(epmc).pdf DeepDyve Pubget Overpricing