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10.1371/journal.ppat.1009742 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009742 34614036!8523079!34614036     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (10): e1009742 Nephropedia Template TP {{tp|p=34614036|t=2021. Impaired function and delayed regeneration of dendritic cells in COVID-19 |pdf=|usr=}}{{34614036}} gab.com Text Impaired function and delayed regeneration of dendritic cells in COVID-19 JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34614036 #FOAvip Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage-HLADR+ cells lacking DC markers. Increased frequency of CD163+ CD14+ cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naive CD4+ T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients. Twit Text FOAVip Impaired function and delayed regeneration of dendritic cells in COVID-19 ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34614036 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34614036 #FOAvip English Wikipedia <ref>{{Cite pmid|34614036}}</ref> Impaired function and delayed regeneration of dendritic cells in COVID-19 #MMPMID34614036 Winheim E; Rinke L; Lutz K; Reischer A; Leutbecher A; Wolfram L; Rausch L; Kranich J; Wratil PR; Huber JE; Baumjohann D; Rothenfusser S; Schubert B; Hilgendorff A; Hellmuth JC; Scherer C; Muenchhoff M; von Bergwelt-Baildon M; Stark K; Straub T; Brocker T; Keppler OT; Subklewe M; Krug AB PLoS Pathog 2021[Oct]; 17 (10): e1009742 PMID34614036show ga Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage-HLADR+ cells lacking DC markers. Increased frequency of CD163+ CD14+ cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naive CD4+ T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients. |Adult[MESH] |Antigens, CD/immunology[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Dendritic Cells/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology/pathology[MESH] |Programmed Cell Death 1 Receptor/immunology[MESH] |Regeneration/*immunology[MESH]Impaired function and delayed regeneration of dendritic cells in COVID(epmc).pdf DeepDyve Pubget Overpricing