Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/acsinfecdis.1c00492 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.1c00492 34613689!ä!34613689 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34613689.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Infect+Dis 2021 ; 7 (11): 2948-2952 Nephropedia Template TP {{tp|p=34613689|t=2021. Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus |pdf=|usr=}}{{34613689}} gab.com Text Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34613689 #FOAvip The tragic consequences of the COVID-19 pandemic have led to admirable responses by the global scientific community, including a profound acceleration in the pace of research and exchange of findings. However, this has had considerable costs of its own, as erroneous conclusions have propagated faster than researchers have been able to detect and correct them. We illustrate the specific misunderstandings that have resulted from reductionist approaches to the study of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which are but one instance of a regrettably growing trend in structural biology. Far from merely being cautionary tales about the conduct of scientific research, these errors have had significant practical impact, by hampering a correct understanding of RdRp structure and mechanism, its inhibition by nucleoside analogues such as remdesivir, and the discovery and characterization of such analogues. After correcting these misunderstandings, we close with several recommendations for a broader correction of the course of scientific research. Twit Text FOAVip Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34613689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34613689 #FOAvip English Wikipedia <ref>{{Cite pmid|34613689}}</ref> Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus #MMPMID34613689 Svetlov D; Artsimovitch I ACS Infect Dis 2021[Nov]; 7 (11): 2948-2952 PMID34613689show ga The tragic consequences of the COVID-19 pandemic have led to admirable responses by the global scientific community, including a profound acceleration in the pace of research and exchange of findings. However, this has had considerable costs of its own, as erroneous conclusions have propagated faster than researchers have been able to detect and correct them. We illustrate the specific misunderstandings that have resulted from reductionist approaches to the study of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which are but one instance of a regrettably growing trend in structural biology. Far from merely being cautionary tales about the conduct of scientific research, these errors have had significant practical impact, by hampering a correct understanding of RdRp structure and mechanism, its inhibition by nucleoside analogues such as remdesivir, and the discovery and characterization of such analogues. After correcting these misunderstandings, we close with several recommendations for a broader correction of the course of scientific research. |*COVID-19[MESH] |*RNA, Viral[MESH] |Antiviral Agents[MESH] |Biology[MESH] |Humans[MESH] |Pandemics[MESH]Reductionism Ad Absurdum: The Misadventures of Structural Biology in t(epmc).pdf DeepDyve Pubget Overpricing