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10.1007/s12275-021-1367-2

http://scihub22266oqcxt.onion/10.1007/s12275-021-1367-2
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suck abstract from ncbi


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pmid34613605      J+Microbiol 2021 ; 59 (11): 1056-1062
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  • Antiviral effects of human placenta hydrolysate (Laennec((R))) against SARS-CoV-2 in vitro and in the ferret model #MMPMID34613605
  • Kim EH; Kim YI; Jang SG; Im M; Jeong K; Choi YK; Han HJ
  • J Microbiol 2021[Nov]; 59 (11): 1056-1062 PMID34613605show ga
  • The COVID-19 pandemic has caused unprecedented health, social, and economic crises worldwide. However, to date, there is an only a limited effective treatment for this disease. Human placenta hydrolysate (hPH) has previously been shown to be safe and to improve the health condition in patients with hyperferritinemia and COVID-19. In this study, we aimed to determine the antiviral effects of hPH against SARS-CoV-2 in vitro and in vivo models and compared with Remdesivir, an FDA-approved drug for COVID-19 treatment. To assess whether hPH inhibited SARS-CoV-2 replication, we determined the CC(50), EC(50), and selective index (SI) in Vero cells by infection with a SARS-CoV-2 at an MOI of 0.01. Further, groups of ferrets infected with 10(5.8) TCID(50)/ml of SARS-CoV-2 and treated with hPH at 2, 4, 6 dpi, and compared their clinical manifestation and virus titers in respiratory tracts with PBS control-treated group. The mRNA expression of immune-related cytokines was determined by qRT-PCR. hPH treatment attenuated virus replication in a dose-dependent manner in vitro. In a ferret infection study, treatment with hPH resulted in minimal bodyweight loss and attenuated virus replication in the nasal wash, turbinates, and lungs of infected ferrets. In addition, qRT-PCR results revealed that the hPH treatment remarkably upregulated the gene expression of type I (IFN-alpha and IFN-beta) and II (IFN-gamma) IFNs in SARS-CoV-2 infected ferrets. Our data collectively suggest that hPH has antiviral efficacy against SARS-CoV-2 and might be a promising therapeutic agent for the treatment of SARS-CoV-2 infection.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Protein Hydrolysates/pharmacology/therapeutic use[MESH]
  • |Adenosine Monophosphate/*analogs & derivatives/pharmacology/therapeutic use[MESH]
  • |Alanine/*analogs & derivatives/pharmacology/therapeutic use[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Female[MESH]
  • |Ferrets[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Placenta/*chemistry[MESH]
  • |Pregnancy[MESH]
  • |SARS-CoV-2/*drug effects[MESH]
  • |Vero Cells[MESH]


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