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10.1039/d1cp02947a

http://scihub22266oqcxt.onion/10.1039/d1cp02947a
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34612386!ä!34612386

suck abstract from ncbi


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pmid34612386      Phys+Chem+Chem+Phys 2021 ; 23 (34): 18461-18474
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  • The key role of the central cavity in sodium transport through ligand-gated two-pore channels #MMPMID34612386
  • Milenkovic S; Bodrenko IV; Carpaneto A; Ceccarelli M
  • Phys Chem Chem Phys 2021[Sep]; 23 (34): 18461-18474 PMID34612386show ga
  • Subcellular and organellar mechanisms have manifested a prominent importance for a broad variety of processes that maintain cellular life at its most basic level. Mammalian two-pore channels (TPCs) appear to be cornerstones of these processes in endo-lysosomes by controlling delicate ion-concentrations in their interiors. With evolutionary remarkable architecture and one-of-a-kind selectivity filter, TPCs are an extremely attractive topic per se. In the light of the current COVID-19 pandemic, hTPC2 emerges to be more than attractive. As a key regulator of the endocytosis pathway, it is potentially essential for diverse viral infections in humans, as demonstrated. Here, by means of multiscale molecular simulations, we propose a model of sodium transport from the lumen to the cytosol where the central cavity works as a reservoir. Since the inhibition of hTPC2 is proven to stop SARS-CoV2 in vitro, shedding light on the hTPC2 function and mechanism is the first step towards the selection of potential inhibiting candidates.
  • |*Ion Channel Gating[MESH]
  • |COVID-19[MESH]
  • |Ligand-Gated Ion Channels/metabolism/*physiology[MESH]
  • |Ligands[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]


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