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10.1016/j.celrep.2021.109823 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109823 34610291!8463313!34610291     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 37 (2): 109823 Nephropedia Template TP {{tp|p=34610291|t=2021. High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines |pdf=|usr=}}{{34610291}} gab.com Text High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34610291 #FOAvip Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case can differ. Here, we compare SARS-CoV-2 spike receptor binding domain (S1-RBD)-specific primary MBCs that form in response to infection or a single mRNA vaccination. Both primary MBC populations have similar frequencies in the blood and respond to a second S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A(+) subset and secondary MBCs that are mostly IgG(+) and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses. Twit Text FOAVip High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34610291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34610291 #FOAvip English Wikipedia <ref>{{Cite pmid|34610291}}</ref> High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines #MMPMID34610291 Pape KA; Dileepan T; Kabage AJ; Kozysa D; Batres R; Evert C; Matson M; Lopez S; Krueger PD; Graiziger C; Vaughn BP; Shmidt E; Rhein J; Schacker TW; Khoruts A; Jenkins MK Cell Rep 2021[Oct]; 37 (2): 109823 PMID34610291show ga Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case can differ. Here, we compare SARS-CoV-2 spike receptor binding domain (S1-RBD)-specific primary MBCs that form in response to infection or a single mRNA vaccination. Both primary MBC populations have similar frequencies in the blood and respond to a second S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A(+) subset and secondary MBCs that are mostly IgG(+) and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses. |Adult[MESH] |Animals[MESH] |Antibodies, Viral/immunology[MESH] |B-Lymphocyte Subsets/immunology[MESH] |B-Lymphocytes/immunology[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/immunology/metabolism[MESH] |Cross Reactions/immunology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunization/methods[MESH] |Immunologic Memory[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Middle Aged[MESH] |Plasma Cells/*immunology[MESH] |RNA, Messenger/immunology[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH] |Vaccination/methods[MESH]High-affinity memory B cells induced by SARS-CoV-2 infection produce m(epmc).pdf DeepDyve Pubget Overpricing