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10.1016/j.isci.2021.103205 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.103205 34608452!8482538!34608452     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (10): 103205 Nephropedia Template TP {{tp|p=34608452|t=2021. Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19 |pdf=|usr=}}{{34608452}} gab.com Text Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34608452 #FOAvip T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidney, liver, and heart obtained at autopsy from COVID-19 patients and matched controls, using the nCounter CAR-T-Characterization panel. We found substantial gene alterations in COVID-19-impacted organs, especially the lung where altered TCR repertoires are noted. Reduced TCR repertoires are also observed in PBMCs of severe COVID-19 patients. ENTPD1/CD39, an ectoenzyme defining exhausted T-cells, is upregulated in the lung, liver, spleen, and PBMCs of severe COVID-19 patients where expression positively correlates with markers of vasculopathy. Heightened ENTPD1/CD39 is paralleled by elevations in STAT-3 and HIF-1alpha transcription factors; and by markedly reduced CD39-antisense-RNA, a long-noncoding-RNA negatively regulating ENTPD1/CD39 at the post-transcriptional level. Limited TCR repertoire and aberrant regulation of ENTPD1/CD39 could have permissive roles in COVID-19 progression and indicate potential therapeutic targets to reverse disease. Twit Text FOAVip Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34608452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34608452 #FOAvip English Wikipedia <ref>{{Cite pmid|34608452}}</ref> Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19 #MMPMID34608452 Wang N; Vuerich M; Kalbasi A; Graham JJ; Csizmadia E; Manickas-Hill ZJ; Woolley A; David C; Miller EM; Gorman K; Hecht JL; Shaefi S; Robson SC; Longhi MS iScience 2021[Oct]; 24 (10): 103205 PMID34608452show ga T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidney, liver, and heart obtained at autopsy from COVID-19 patients and matched controls, using the nCounter CAR-T-Characterization panel. We found substantial gene alterations in COVID-19-impacted organs, especially the lung where altered TCR repertoires are noted. Reduced TCR repertoires are also observed in PBMCs of severe COVID-19 patients. ENTPD1/CD39, an ectoenzyme defining exhausted T-cells, is upregulated in the lung, liver, spleen, and PBMCs of severe COVID-19 patients where expression positively correlates with markers of vasculopathy. Heightened ENTPD1/CD39 is paralleled by elevations in STAT-3 and HIF-1alpha transcription factors; and by markedly reduced CD39-antisense-RNA, a long-noncoding-RNA negatively regulating ENTPD1/CD39 at the post-transcriptional level. Limited TCR repertoire and aberrant regulation of ENTPD1/CD39 could have permissive roles in COVID-19 progression and indicate potential therapeutic targets to reverse disease. äLimited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-(epmc).pdf DeepDyve Pubget Overpricing