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10.4049/jimmunol.2100606 http://scihub22266oqcxt.onion/10.4049/jimmunol.2100606 34607939!ä!34607939 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2021 ; 207 (10): 2581-2588 Nephropedia Template TP {{tp|p=34607939|t=2021. SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals |pdf=|usr=}}{{34607939}} gab.com Text SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34607939 #FOAvip SARS-CoV-2 is a respiratory pathogen that can cause severe disease in at-risk populations but results in asymptomatic infections or a mild course of disease in the majority of cases. We report the identification of SARS-CoV-2-reactive B cells in human tonsillar tissue obtained from children who were negative for coronavirus disease 2019 prior to the pandemic and the generation of mAbs recognizing the SARS-CoV-2 Spike protein from these B cells. These Abs showed reduced binding to Spike proteins of SARS-CoV-2 variants and did not recognize Spike proteins of endemic coronaviruses, but subsets reacted with commensal microbiota and exhibited SARS-CoV-2-neutralizing potential. Our study demonstrates pre-existing SARS-CoV-2-reactive Abs in various B cell populations in the upper respiratory tract lymphoid tissue that may lead to the rapid engagement of the pathogen and contribute to prevent manifestations of symptomatic or severe disease. Twit Text FOAVip SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34607939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34607939 #FOAvip English Wikipedia <ref>{{Cite pmid|34607939}}</ref> SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals #MMPMID34607939 Liu Y; Budylowski P; Dong S; Li Z; Goroshko S; Leung LYT; Grunebaum E; Campisi P; Propst EJ; Wolter NE; Rini JM; Zia A; Ostrowski M; Ehrhardt GRA J Immunol 2021[Nov]; 207 (10): 2581-2588 PMID34607939show ga SARS-CoV-2 is a respiratory pathogen that can cause severe disease in at-risk populations but results in asymptomatic infections or a mild course of disease in the majority of cases. We report the identification of SARS-CoV-2-reactive B cells in human tonsillar tissue obtained from children who were negative for coronavirus disease 2019 prior to the pandemic and the generation of mAbs recognizing the SARS-CoV-2 Spike protein from these B cells. These Abs showed reduced binding to Spike proteins of SARS-CoV-2 variants and did not recognize Spike proteins of endemic coronaviruses, but subsets reacted with commensal microbiota and exhibited SARS-CoV-2-neutralizing potential. Our study demonstrates pre-existing SARS-CoV-2-reactive Abs in various B cell populations in the upper respiratory tract lymphoid tissue that may lead to the rapid engagement of the pathogen and contribute to prevent manifestations of symptomatic or severe disease. |Adenoids/*immunology[MESH] |Antibodies, Viral/metabolism[MESH] |B-Lymphocyte Subsets/*immunology[MESH] |B-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Child[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Lymphocyte Activation[MESH] |Mucous Membrane/*immunology[MESH] |Receptors, Antigen, B-Cell/*genetics[MESH] |Respiratory System/*immunology[MESH] |SARS-CoV-2/*physiology[MESH] |Single-Cell Analysis[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of (epmc).pdf DeepDyve Pubget Overpricing