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10.1016/j.jmb.2021.167280 http://scihub22266oqcxt.onion/10.1016/j.jmb.2021.167280 34606831!8485708!34606831     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2022 ; 434 (6): 167280 Nephropedia Template TP {{tp|p=34606831|t=2022. The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation |pdf=|usr=}}{{34606831}} gab.com Text The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34606831 #FOAvip Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected cell interacts with receptors on neighboring cells. Syncytia may potentially contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammatory response. SARS-CoV-2 variants of concern possess several mutations within the S protein that enhance receptor interaction, fusogenicity and antibody binding. In this review, we discuss the molecular determinants of S mediated fusion and the antiviral innate immunity components that counteract syncytia formation. Several interferon-stimulated genes, including IFITMs and LY6E act as barriers to S protein-mediated fusion by altering the composition or biophysical properties of the target membrane. We also summarize the effect that the mutations associated with the variants of concern have on S protein fusogenicity. Altogether, this review contextualizes the current understanding of Spike fusogenicity and the role of syncytia during SARS-CoV-2 infection and pathology. Twit Text FOAVip The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34606831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34606831 #FOAvip English Wikipedia <ref>{{Cite pmid|34606831}}</ref> The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation #MMPMID34606831 Rajah MM; Bernier A; Buchrieser J; Schwartz O J Mol Biol 2022[Mar]; 434 (6): 167280 PMID34606831show ga Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected cell interacts with receptors on neighboring cells. Syncytia may potentially contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammatory response. SARS-CoV-2 variants of concern possess several mutations within the S protein that enhance receptor interaction, fusogenicity and antibody binding. In this review, we discuss the molecular determinants of S mediated fusion and the antiviral innate immunity components that counteract syncytia formation. Several interferon-stimulated genes, including IFITMs and LY6E act as barriers to S protein-mediated fusion by altering the composition or biophysical properties of the target membrane. We also summarize the effect that the mutations associated with the variants of concern have on S protein fusogenicity. Altogether, this review contextualizes the current understanding of Spike fusogenicity and the role of syncytia during SARS-CoV-2 infection and pathology. |*COVID-19/immunology/virology[MESH] |*Giant Cells/virology[MESH] |*Interferons/metabolism[MESH] |*SARS-CoV-2/physiology[MESH] |*Spike Glycoprotein, Coronavirus/genetics[MESH] |*Virus Internalization[MESH] |Humans[MESH] |Immunity, Innate[MESH]The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and(epmc).pdf DeepDyve Pubget Overpricing