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10.3389/fimmu.2021.709759 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.709759 34603283!8484961!34603283     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34603283&cmd=llinks): Failed to open stream: HTTP request failed! 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Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals |pdf=|usr=}}{{34603283}} gab.com Text Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34603283 #FOAvip The clinical features of SARS-CoV-2 infection range from asymptomatic to severe disease with life-threatening complications. Understanding the persistence of immune responses in asymptomatic individuals merit special attention because of their importance in controlling the spread of the infections. We here studied the antibody and T cell responses, and a wide range of inflammation markers, in 56 SARS-CoV-2 antibody-positive individuals, identified by a population screen after the first wave of SARS-CoV-2 infection. These, mostly asymptomatic individuals, were reanalyzed 7-8 months after their infection together with 115 age-matched seronegative controls. We found that 7-8 months after the infection their antibodies to SARS-CoV-2 Nucleocapsid (N) protein declined whereas we found no decrease in the antibodies to Spike receptor-binding domain (S-RBD) when compared to the findings at seropositivity identification. In contrast to antibodies to N protein, the antibodies to S-RBD correlated with the viral neutralization capacity and with CD4(+) T cell responses as measured by antigen-specific upregulation of CD137 and CD69 markers. Unexpectedly we found the asymptomatic antibody-positive individuals to have increased serum levels of S100A12, TGF-alpha, IL18, and OSM, the markers of activated macrophages-monocytes, suggesting long-term persistent inflammatory effect associated with the viral infection in asymptomatic individuals. Our results support the evidence for the long-term persistence of the inflammation process and the need for post-infection clinical monitoring of SARS-CoV-2 infected asymptomatic individuals. Twit Text FOAVip Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34603283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34603283 #FOAvip English Wikipedia <ref>{{Cite pmid|34603283}}</ref> Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals #MMPMID34603283 Tserel L; Jogi P; Naaber P; Maslovskaja J; Haling A; Salumets A; Zusinaite E; Soeorg H; Lattekivi F; Ingerainen D; Soots M; Toompere K; Kaarna K; Kisand K; Lutsar I; Peterson P Front Immunol 2021[]; 12 (ä): 709759 PMID34603283show ga The clinical features of SARS-CoV-2 infection range from asymptomatic to severe disease with life-threatening complications. Understanding the persistence of immune responses in asymptomatic individuals merit special attention because of their importance in controlling the spread of the infections. We here studied the antibody and T cell responses, and a wide range of inflammation markers, in 56 SARS-CoV-2 antibody-positive individuals, identified by a population screen after the first wave of SARS-CoV-2 infection. These, mostly asymptomatic individuals, were reanalyzed 7-8 months after their infection together with 115 age-matched seronegative controls. We found that 7-8 months after the infection their antibodies to SARS-CoV-2 Nucleocapsid (N) protein declined whereas we found no decrease in the antibodies to Spike receptor-binding domain (S-RBD) when compared to the findings at seropositivity identification. In contrast to antibodies to N protein, the antibodies to S-RBD correlated with the viral neutralization capacity and with CD4(+) T cell responses as measured by antigen-specific upregulation of CD137 and CD69 markers. Unexpectedly we found the asymptomatic antibody-positive individuals to have increased serum levels of S100A12, TGF-alpha, IL18, and OSM, the markers of activated macrophages-monocytes, suggesting long-term persistent inflammatory effect associated with the viral infection in asymptomatic individuals. Our results support the evidence for the long-term persistence of the inflammation process and the need for post-infection clinical monitoring of SARS-CoV-2 infected asymptomatic individuals. |*Asymptomatic Infections[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/*blood/immunology[MESH] |CD4 Lymphocyte Count[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*pathology[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Humans[MESH] |Inflammation Mediators/*blood[MESH] |Inflammation/immunology[MESH] |Interleukin-18/blood[MESH] |Macrophages/immunology[MESH] |Monocytes/immunology[MESH] |Oncostatin M/blood[MESH] |Phosphoproteins/immunology[MESH] |Protein Domains/immunology[MESH] |S100A12 Protein/blood[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-Co(epmc).pdf DeepDyve Pubget Overpricing