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10.1371/journal.ppat.1009412 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009412 34597346!8513853!34597346     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34597346.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2021 ; 17 (10): e1009412 Nephropedia Template TP {{tp|p=34597346|t=2021. The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation |pdf=|usr=}}{{34597346}} gab.com Text The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34597346 #FOAvip Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics. This identified viral proteins at specific intracellular locations, such as association of accessary proteins with intracellular membranes, and projected SARS-CoV-2 impacts on innate immune signaling, ER-Golgi transport, and protein translation. It identified viral protein adjacency to specific host proteins whose regulatory variants are linked to COVID-19 severity, including the TRIM4 interferon signaling regulator which was found proximal to the SARS-CoV-2 M protein. Viral NSP1 protein adjacency to the EIF3 complex was associated with inhibited host protein translation whereas ORF6 localization with MAVS was associated with inhibited RIG-I 2CARD-mediated IFNB1 promoter activation. Quantitative proteomics identified candidate host targets for the NSP5 protease, with specific functional cleavage sequences in host proteins CWC22 and FANCD2. This data resource identifies host factors proximal to viral proteins in living human cells and nominates pathogenic mechanisms employed by SARS-CoV-2. Twit Text FOAVip The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34597346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34597346 #FOAvip English Wikipedia <ref>{{Cite pmid|34597346}}</ref> The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation #MMPMID34597346 Meyers JM; Ramanathan M; Shanderson RL; Beck A; Donohue L; Ferguson I; Guo MG; Rao DS; Miao W; Reynolds D; Yang X; Zhao Y; Yang YY; Blish C; Wang Y; Khavari PA PLoS Pathog 2021[Oct]; 17 (10): e1009412 PMID34597346show ga Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics. This identified viral proteins at specific intracellular locations, such as association of accessary proteins with intracellular membranes, and projected SARS-CoV-2 impacts on innate immune signaling, ER-Golgi transport, and protein translation. It identified viral protein adjacency to specific host proteins whose regulatory variants are linked to COVID-19 severity, including the TRIM4 interferon signaling regulator which was found proximal to the SARS-CoV-2 M protein. Viral NSP1 protein adjacency to the EIF3 complex was associated with inhibited host protein translation whereas ORF6 localization with MAVS was associated with inhibited RIG-I 2CARD-mediated IFNB1 promoter activation. Quantitative proteomics identified candidate host targets for the NSP5 protease, with specific functional cleavage sequences in host proteins CWC22 and FANCD2. This data resource identifies host factors proximal to viral proteins in living human cells and nominates pathogenic mechanisms employed by SARS-CoV-2. |COVID-19/*metabolism[MESH] |Host-Parasite Interactions/*physiology[MESH] |Humans[MESH] |Protein Biosynthesis/physiology[MESH] |Proteome/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH]The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted ant(epmc).pdf DeepDyve Pubget Overpricing