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10.1038/s41592-021-01274-5 http://scihub22266oqcxt.onion/10.1038/s41592-021-01274-5 34594031!8493809!34594031     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Methods 2021 ; 18 (10): 1181-1191 Nephropedia Template TP {{tp|p=34594031|t=2021. Systematic investigation of cytokine signaling activity at the tissue and single-cell levels |pdf=|usr=}}{{34594031}} gab.com Text Systematic investigation of cytokine signaling activity at the tissue and single-cell levels JO: Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=34594031 #FOAvip Cytokines are critical for intercellular communication in human health and disease, but the investigation of cytokine signaling activity has remained challenging due to the short half-lives of cytokines and the complexity/redundancy of cytokine functions. To address these challenges, we developed the Cytokine Signaling Analyzer (CytoSig; https://cytosig.ccr.cancer.gov/ ), providing both a database of target genes modulated by cytokines and a predictive model of cytokine signaling cascades from transcriptomic profiles. We collected 20,591 transcriptome profiles for human cytokine, chemokine and growth factor responses. This atlas of transcriptional patterns induced by cytokines enabled the reliable prediction of signaling activities in distinct cell populations in infectious diseases, chronic inflammation and cancer using bulk and single-cell transcriptomic data. CytoSig revealed previously unidentified roles of many cytokines, such as BMP6 as an anti-inflammatory factor, and identified candidate therapeutic targets in human inflammatory diseases, such as CXCL8 for severe coronavirus disease 2019. Twit Text FOAVip Systematic investigation of cytokine signaling activity at the tissue and single-cell levels ????Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=34594031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34594031 #FOAvip English Wikipedia <ref>{{Cite pmid|34594031}}</ref> Systematic investigation of cytokine signaling activity at the tissue and single-cell levels #MMPMID34594031 Jiang P; Zhang Y; Ru B; Yang Y; Vu T; Paul R; Mirza A; Altan-Bonnet G; Liu L; Ruppin E; Wakefield L; Wucherpfennig KW Nat Methods 2021[Oct]; 18 (10): 1181-1191 PMID34594031show ga Cytokines are critical for intercellular communication in human health and disease, but the investigation of cytokine signaling activity has remained challenging due to the short half-lives of cytokines and the complexity/redundancy of cytokine functions. To address these challenges, we developed the Cytokine Signaling Analyzer (CytoSig; https://cytosig.ccr.cancer.gov/ ), providing both a database of target genes modulated by cytokines and a predictive model of cytokine signaling cascades from transcriptomic profiles. We collected 20,591 transcriptome profiles for human cytokine, chemokine and growth factor responses. This atlas of transcriptional patterns induced by cytokines enabled the reliable prediction of signaling activities in distinct cell populations in infectious diseases, chronic inflammation and cancer using bulk and single-cell transcriptomic data. CytoSig revealed previously unidentified roles of many cytokines, such as BMP6 as an anti-inflammatory factor, and identified candidate therapeutic targets in human inflammatory diseases, such as CXCL8 for severe coronavirus disease 2019. |*Databases, Protein[MESH] |*SARS-CoV-2[MESH] |COVID-19/*immunology/metabolism[MESH] |Cytokines/genetics/*metabolism[MESH] |Gene Expression Regulation/immunology/physiology[MESH] |Humans[MESH]Systematic investigation of cytokine signaling activity at the tissue (epmc).pdf DeepDyve Pubget Overpricing