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10.1016/j.tem.2021.08.011 http://scihub22266oqcxt.onion/10.1016/j.tem.2021.08.011 34593305!8423996!34593305     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Endocrinol+Metab 2021 ; 32 (11): 875-889 Nephropedia Template TP {{tp|p=34593305|t=2021. GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism |pdf=|usr=}}{{34593305}} gab.com Text GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism JO: Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=34593305 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of respiratory and cardiovascular diseases, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes the structural proteins spike (S), envelope (E), membrane (M), and nucleocapsid (N). The receptor-binding domain on the surface subunit S1 is responsible for attachment of the virus to angiotensin (Ang)-converting enzyme 2 (ACE2), which is highly expressed in host cells. The cytokine storm observed in patients with COVID-19 contributes to the endothelial vascular dysfunction, which can lead to acute respiratory distress syndrome, multiorgan failure, alteration in iron homeostasis, and death. Growth and differentiation factor 15 (GDF15), which belongs to the transforming growth factor-beta (TGF-beta) superfamily of proteins, has a pivotal role in the development and progression of diseases because of its role as a metabolic regulator. In COVID-19, GDF15 activity increases in response to tissue damage. GDF15 appears to be a strong predictor of poor outcomes in patients critically ill with COVID-19 and acts as an 'inflammation-induced central mediator of tissue tolerance' via its metabolic properties. In this review, we examine the potential properties of GDF15 as an emerging modulator of immunity in COVID-19 in association with iron metabolism. The virus life cycle in host cell provides potential targets for drug therapy. Twit Text FOAVip GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism ????Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=34593305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34593305 #FOAvip English Wikipedia <ref>{{Cite pmid|34593305}}</ref> GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism #MMPMID34593305 Rochette L; Zeller M; Cottin Y; Vergely C Trends Endocrinol Metab 2021[Nov]; 32 (11): 875-889 PMID34593305show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of respiratory and cardiovascular diseases, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes the structural proteins spike (S), envelope (E), membrane (M), and nucleocapsid (N). The receptor-binding domain on the surface subunit S1 is responsible for attachment of the virus to angiotensin (Ang)-converting enzyme 2 (ACE2), which is highly expressed in host cells. The cytokine storm observed in patients with COVID-19 contributes to the endothelial vascular dysfunction, which can lead to acute respiratory distress syndrome, multiorgan failure, alteration in iron homeostasis, and death. Growth and differentiation factor 15 (GDF15), which belongs to the transforming growth factor-beta (TGF-beta) superfamily of proteins, has a pivotal role in the development and progression of diseases because of its role as a metabolic regulator. In COVID-19, GDF15 activity increases in response to tissue damage. GDF15 appears to be a strong predictor of poor outcomes in patients critically ill with COVID-19 and acts as an 'inflammation-induced central mediator of tissue tolerance' via its metabolic properties. In this review, we examine the potential properties of GDF15 as an emerging modulator of immunity in COVID-19 in association with iron metabolism. The virus life cycle in host cell provides potential targets for drug therapy. |Apoptosis/immunology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology/metabolism[MESH] |Cytokine Release Syndrome/*immunology/metabolism[MESH] |Endothelium, Vascular/*immunology/metabolism/physiopathology[MESH] |Glial Cell Line-Derived Neurotrophic Factor Receptors/immunology/metabolism[MESH] |Growth Differentiation Factor 15/*immunology/metabolism[MESH] |Humans[MESH] |Immunologic Factors/therapeutic use[MESH] |Iron/*metabolism[MESH] |Oxidative Stress/immunology[MESH] |Prognosis[MESH] |Pyroptosis/immunology[MESH]GDF15: an emerging modulator of immunity and a strategy in COVID-19 in(epmc).pdf DeepDyve Pubget Overpricing