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10.1186/s12916-021-02103-4 http://scihub22266oqcxt.onion/10.1186/s12916-021-02103-4 34593004!8483940!34593004     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2021 ; 19 (1): 255 Nephropedia Template TP {{tp|p=34593004|t=2021. Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections |pdf=|usr=}}{{34593004}} gab.com Text Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=34593004 #FOAvip BACKGROUND: This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health. METHODS: Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by qPCR (quantitative polymerase chain reaction) for Wuhan-Hu1 and alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant. GATK (genome analysis toolkit) variants were filtered with allele fraction >/=80 and min read depth 30x. RESULTS: Viral sequencing revealed an infection cluster of 6 vaccinated patients infected with the delta (B.1.617.2) SARS-CoV-2 variant. With no history of vaccine breakthrough, this suggests the delta variant may possess immune evasion in patients that received the Pfizer BNT162b2, Moderna mRNA-1273, and Covaxin BBV152. CONCLUSIONS: Delta variant may pose the highest risk out of any currently circulating SARS-CoV-2 variants, with previously described increased transmissibility over alpha variant and now, possible vaccine breakthrough. FUNDING: Parts of this work was supported by the National Institute of Allergy and Infectious Diseases (1U19AI144297) and Baylor College of Medicine internal funding. Twit Text FOAVip Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=34593004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34593004 #FOAvip English Wikipedia <ref>{{Cite pmid|34593004}}</ref> Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections #MMPMID34593004 Farinholt T; Doddapaneni H; Qin X; Menon V; Meng Q; Metcalf G; Chao H; Gingras MC; Avadhanula V; Farinholt P; Agrawal C; Muzny DM; Piedra PA; Gibbs RA; Petrosino J BMC Med 2021[Oct]; 19 (1): 255 PMID34593004show ga BACKGROUND: This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health. METHODS: Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by qPCR (quantitative polymerase chain reaction) for Wuhan-Hu1 and alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant. GATK (genome analysis toolkit) variants were filtered with allele fraction >/=80 and min read depth 30x. RESULTS: Viral sequencing revealed an infection cluster of 6 vaccinated patients infected with the delta (B.1.617.2) SARS-CoV-2 variant. With no history of vaccine breakthrough, this suggests the delta variant may possess immune evasion in patients that received the Pfizer BNT162b2, Moderna mRNA-1273, and Covaxin BBV152. CONCLUSIONS: Delta variant may pose the highest risk out of any currently circulating SARS-CoV-2 variants, with previously described increased transmissibility over alpha variant and now, possible vaccine breakthrough. FUNDING: Parts of this work was supported by the National Institute of Allergy and Infectious Diseases (1U19AI144297) and Baylor College of Medicine internal funding. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |BNT162 Vaccine[MESH] |COVID-19 Vaccines[MESH] |Humans[MESH]Transmission event of SARS-CoV-2 delta variant reveals multiple vaccin(epmc).pdf DeepDyve Pubget Overpricing