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10.1016/j.immuni.2021.09.002 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.09.002 34592166!8416549!34592166     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (11): 2650-2669.e14 Nephropedia Template TP {{tp|p=34592166|t=2021. Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 |pdf=|usr=}}{{34592166}} gab.com Text Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34592166 #FOAvip Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-alpha plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-alpha signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. NK cells exert anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity but are functionally impaired in severe COVID-19. Further, NK cell dysfunction may be relevant for the development of fibrotic lung disease in severe COVID-19, as NK cells exhibited impaired anti-fibrotic activity. Our study indicates preferential IFN-alpha and TNF responses in severe and moderate COVID-19, respectively, and associates a prolonged IFN-alpha-induced NK cell response with poorer disease outcome. Twit Text FOAVip Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34592166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34592166 #FOAvip English Wikipedia <ref>{{Cite pmid|34592166}}</ref> Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 #MMPMID34592166 Kramer B; Knoll R; Bonaguro L; ToVinh M; Raabe J; Astaburuaga-Garcia R; Schulte-Schrepping J; Kaiser KM; Rieke GJ; Bischoff J; Monin MB; Hoffmeister C; Schlabe S; De Domenico E; Reusch N; Handler K; Reynolds G; Bluthgen N; Hack G; Finnemann C; Nischalke HD; Strassburg CP; Stephenson E; Su Y; Gardner L; Yuan D; Chen D; Goldman J; Rosenstiel P; Schmidt SV; Latz E; Hrusovsky K; Ball AJ; Johnson JM; Koenig PA; Schmidt FI; Haniffa M; Heath JR; Kummerer BM; Keitel V; Jensen B; Stubbemann P; Kurth F; Sander LE; Sawitzki B; Aschenbrenner AC; Schultze JL; Nattermann J Immunity 2021[Nov]; 54 (11): 2650-2669.e14 PMID34592166show ga Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-alpha plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-alpha signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. NK cells exert anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity but are functionally impaired in severe COVID-19. Further, NK cell dysfunction may be relevant for the development of fibrotic lung disease in severe COVID-19, as NK cells exhibited impaired anti-fibrotic activity. Our study indicates preferential IFN-alpha and TNF responses in severe and moderate COVID-19, respectively, and associates a prolonged IFN-alpha-induced NK cell response with poorer disease outcome. |Base Sequence[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Inflammation/immunology[MESH] |Interferon-alpha/blood/*immunology[MESH] |Killer Cells, Natural/*immunology[MESH] |Pulmonary Fibrosis/pathology[MESH] |RNA-Seq[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH] |Transcriptome/genetics[MESH] |Tumor Necrosis Factor-alpha/*metabolism[MESH] |United Kingdom[MESH]Early IFN-alpha signatures and persistent dysfunction are distinguishi(epmc).pdf DeepDyve Pubget Overpricing