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10.1038/s41598-021-98873-1

http://scihub22266oqcxt.onion/10.1038/s41598-021-98873-1
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34588541!8481283!34588541
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suck abstract from ncbi


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pmid34588541      Sci+Rep 2021 ; 11 (1): 19373
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  • Retinal vessels modifications in acute and post-COVID-19 #MMPMID34588541
  • Invernizzi A; Schiuma M; Parrulli S; Torre A; Zicarelli F; Colombo V; Marini S; Villella E; Bertoni A; Antinori S; Rizzardini G; Galli M; Meroni L; Giacomelli A; Staurenghi G
  • Sci Rep 2021[Sep]; 11 (1): 19373 PMID34588541show ga
  • Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 +/- 10.9 to 92.2 +/- 11.4 microm, p < 0.0001 and from 133.1 +/- 19.3 to 124.6 +/- 16.1 microm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*complications[MESH]
  • |Female[MESH]
  • |Fluorescein Angiography[MESH]
  • |Fundus Oculi[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retina/diagnostic imaging/pathology[MESH]
  • |Retinal Vessels/*pathology[MESH]
  • |SARS-CoV-2[MESH]


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