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10.1126/science.abj3624 http://scihub22266oqcxt.onion/10.1126/science.abj3624 34581622!7612834!34581622     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 374 (6567): eabj3624 Nephropedia Template TP {{tp|p=34581622|t=2021. A prenylated dsRNA sensor protects against severe COVID-19 |pdf=|usr=}}{{34581622}} gab.com Text A prenylated dsRNA sensor protects against severe COVID-19 JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34581622 #FOAvip Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that 2'-5'-oligoadenylate synthetase 1 (OAS1), through ribonuclease L, potently inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We show that a common splice-acceptor single-nucleotide polymorphism (Rs10774671) governs whether patients express prenylated OAS1 isoforms that are membrane-associated and sense-specific regions of SARS-CoV-2 RNAs or if they only express cytosolic, nonprenylated OAS1 that does not efficiently detect SARS-CoV-2. In hospitalized patients, expression of prenylated OAS1 was associated with protection from severe COVID-19, suggesting that this antiviral defense is a major component of a protective antiviral response. Twit Text FOAVip A prenylated dsRNA sensor protects against severe COVID-19 ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34581622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34581622 #FOAvip English Wikipedia <ref>{{Cite pmid|34581622}}</ref> A prenylated dsRNA sensor protects against severe COVID-19 #MMPMID34581622 Wickenhagen A; Sugrue E; Lytras S; Kuchi S; Noerenberg M; Turnbull ML; Loney C; Herder V; Allan J; Jarmson I; Cameron-Ruiz N; Varjak M; Pinto RM; Lee JY; Iselin L; Palmalux N; Stewart DG; Swingler S; Greenwood EJD; Crozier TWM; Gu Q; Davies EL; Clohisey S; Wang B; Trindade Maranhao Costa F; Freire Santana M; de Lima Ferreira LC; Murphy L; Fawkes A; Meynert A; Grimes G; Da Silva Filho JL; Marti M; Hughes J; Stanton RJ; Wang ECY; Ho A; Davis I; Jarrett RF; Castello A; Robertson DL; Semple MG; Openshaw PJM; Palmarini M; Lehner PJ; Baillie JK; Rihn SJ; Wilson SJ Science 2021[Oct]; 374 (6567): eabj3624 PMID34581622show ga Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that 2'-5'-oligoadenylate synthetase 1 (OAS1), through ribonuclease L, potently inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We show that a common splice-acceptor single-nucleotide polymorphism (Rs10774671) governs whether patients express prenylated OAS1 isoforms that are membrane-associated and sense-specific regions of SARS-CoV-2 RNAs or if they only express cytosolic, nonprenylated OAS1 that does not efficiently detect SARS-CoV-2. In hospitalized patients, expression of prenylated OAS1 was associated with protection from severe COVID-19, suggesting that this antiviral defense is a major component of a protective antiviral response. |2',5'-Oligoadenylate Synthetase/*genetics/*metabolism[MESH] |5' Untranslated Regions[MESH] |A549 Cells[MESH] |Animals[MESH] |COVID-19/enzymology/*genetics/immunology/*physiopathology[MESH] |Chiroptera/genetics/virology[MESH] |Coronaviridae/enzymology/genetics/physiology[MESH] |Endoribonucleases/metabolism[MESH] |Humans[MESH] |Interferons/immunology[MESH] |Isoenzymes/genetics/metabolism[MESH] |Phosphoric Diester Hydrolases/genetics/metabolism[MESH] |Polymorphism, Single Nucleotide[MESH] |Protein Prenylation[MESH] |RNA, Double-Stranded/chemistry/genetics/*metabolism[MESH] |RNA, Viral/chemistry/genetics/*metabolism[MESH] |Retroelements[MESH] |SARS-CoV-2/genetics/*physiology[MESH] |Severity of Illness Index[MESH]A prenylated dsRNA sensor protects against severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing