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10.1155/2021/4129993 http://scihub22266oqcxt.onion/10.1155/2021/4129993 34580601!8463930!34580601     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34580601&cmd=llinks): Failed to open stream: HTTP request failed! 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Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation |pdf=|usr=}}{{34580601}} gab.com Text Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation JO: Dis Markers http://www.kidney.de/pget.php?&tw=1&pmid=34580601 #FOAvip Hyperinflammation is related to the development of COVID-19. Resveratrol is considered an anti-inflammatory and antiviral agent. Herein, we used a network pharmacological approach and bioinformatic gene analysis to explore the pharmacological mechanism of Resveratrol in COVID-19 therapy. Potential targets of Resveratrol were obtained from public databases. SARS-CoV-2 differentially expressed genes (DEGs) were screened out via bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE147507, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis; then, protein-protein interaction network was constructed. The common targets, GO terms, and KEGG pathways of Resveratrol targets and SARS-CoV-2 DEGs were confirmed. KEGG Mapper queried the location of common targets in the key pathways. A notable overlap of the GO terms and KEGG pathways between Resveratrol targets and SARS-CoV-2 DEGs was revealed. The shared targets between Resveratrol targets and SARS-CoV-2 mainly involved the IL-17 signaling pathway, NF-kappa B signaling pathway, and TNF signaling pathway. Our study uncovered that Resveratrol is a promising therapeutic candidate for COVID-19 and we also revealed the probable key targets and pathways involved. Ultimately, we bring forward new insights and encourage more studies on Resveratol to benefit COVID-19 patients. Twit Text FOAVip Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation ????Dis Markers http://www.kidney.de/pget.php?&tw=1&pmid=34580601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34580601 #FOAvip English Wikipedia <ref>{{Cite pmid|34580601}}</ref> Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation #MMPMID34580601 Xiao Z; Ye Q; Duan X; Xiang T Dis Markers 2021[]; 2021 (ä): 4129993 PMID34580601show ga Hyperinflammation is related to the development of COVID-19. Resveratrol is considered an anti-inflammatory and antiviral agent. Herein, we used a network pharmacological approach and bioinformatic gene analysis to explore the pharmacological mechanism of Resveratrol in COVID-19 therapy. Potential targets of Resveratrol were obtained from public databases. SARS-CoV-2 differentially expressed genes (DEGs) were screened out via bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE147507, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis; then, protein-protein interaction network was constructed. The common targets, GO terms, and KEGG pathways of Resveratrol targets and SARS-CoV-2 DEGs were confirmed. KEGG Mapper queried the location of common targets in the key pathways. A notable overlap of the GO terms and KEGG pathways between Resveratrol targets and SARS-CoV-2 DEGs was revealed. The shared targets between Resveratrol targets and SARS-CoV-2 mainly involved the IL-17 signaling pathway, NF-kappa B signaling pathway, and TNF signaling pathway. Our study uncovered that Resveratrol is a promising therapeutic candidate for COVID-19 and we also revealed the probable key targets and pathways involved. Ultimately, we bring forward new insights and encourage more studies on Resveratol to benefit COVID-19 patients. |Anti-Inflammatory Agents/*therapeutic use[MESH] |COVID-19/*complications/virology[MESH] |Gene Ontology[MESH] |Genes, Viral[MESH] |Humans[MESH] |Inflammation/*drug therapy/etiology[MESH] |Molecular Docking Simulation[MESH] |Protein Interaction Maps[MESH] |Resveratrol/chemistry/*therapeutic use[MESH]Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-R(epmc).pdf DeepDyve Pubget Overpricing