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10.3390/ijms221810075

http://scihub22266oqcxt.onion/10.3390/ijms221810075
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34576237!8466540!34576237
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suck abstract from ncbi


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pmid34576237      Int+J+Mol+Sci 2021 ; 22 (18): ä
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  • Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses #MMPMID34576237
  • Mese K; Bunz O; Volkwein W; Vemulapalli SPB; Zhang W; Schellhorn S; Heenemann K; Rueckner A; Sing A; Vahlenkamp TW; Severing AL; Gao J; Aydin M; Jung D; Bachmann HS; Zanker KS; Busch U; Baiker A; Griesinger C; Ehrhardt A
  • Int J Mol Sci 2021[Sep]; 22 (18): ä PMID34576237show ga
  • Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.
  • |Acyclovir/pharmacology[MESH]
  • |Adenoviruses, Human/drug effects/physiology[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/chemistry/*pharmacology[MESH]
  • |CHO Cells[MESH]
  • |Cell Line, Tumor[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Cricetulus[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Fibroblasts[MESH]
  • |Heparin/chemistry/*pharmacology[MESH]
  • |Herpesvirus 1, Human/drug effects/physiology[MESH]
  • |Humans[MESH]
  • |Magnesium Chloride/chemistry/*pharmacology[MESH]
  • |Magnetic Resonance Spectroscopy[MESH]
  • |Microbial Sensitivity Tests[MESH]
  • |Molecular Structure[MESH]
  • |Primary Cell Culture[MESH]
  • |SARS-CoV-2/drug effects/physiology[MESH]
  • |Structure-Activity Relationship[MESH]
  • |Vero Cells[MESH]
  • |Viral Load/drug effects[MESH]


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