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10.3390/biomedicines9091142

http://scihub22266oqcxt.onion/10.3390/biomedicines9091142
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34572329!8466119!34572329
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suck abstract from ncbi


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pmid34572329      Biomedicines 2021 ; 9 (9): ä
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  • Epigenetic Mechanisms Underlying COVID-19 Pathogenesis #MMPMID34572329
  • Kaneko S; Takasawa K; Asada K; Shinkai N; Bolatkan A; Yamada M; Takahashi S; Machino H; Kobayashi K; Komatsu M; Hamamoto R
  • Biomedicines 2021[Sep]; 9 (9): ä PMID34572329show ga
  • In 2019, a novel severe acute respiratory syndrome called coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was reported and was declared a pandemic by the World Health Organization (WHO) in March 2020. With the advancing development of COVID-19 vaccines and their administration globally, it is expected that COVID-19 will converge in the future; however, the situation remains unpredictable because of a series of reports regarding SARS-CoV-2 variants. Currently, there are still few specific effective treatments for COVID-19, as many unanswered questions remain regarding the pathogenic mechanism of COVID-19. Continued elucidation of COVID-19 pathogenic mechanisms is a matter of global importance. In this regard, recent reports have suggested that epigenetics plays an important role; for instance, the expression of angiotensin I converting enzyme 2 (ACE2) receptor, an important factor in human infection with SARS-CoV-2, is epigenetically regulated; further, DNA methylation status is reported to be unique to patients with COVID-19. In this review, we focus on epigenetic mechanisms to provide a new molecular framework for elucidating the pathogenesis of SARS-CoV-2 infection in humans and of COVID-19, along with the possibility of new diagnostic and therapeutic strategies.
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