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10.3390/cells10092427 http://scihub22266oqcxt.onion/10.3390/cells10092427 34572076!8467010!34572076     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (9): ä Nephropedia Template TP {{tp|p=34572076|t=2021. Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets |pdf=|usr=}}{{34572076}} gab.com Text Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34572076 #FOAvip Coronavirus disease 19 (COVID-19) is caused by an enveloped, positive-sense, single-stranded RNA virus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the realm Riboviria, order Nidovirales, family Coronaviridae, genus Betacoronavirus and the species Severe acute respiratory syndrome-related coronavirus. This viral disease is characterized by a myriad of varying symptoms, such as pyrexia, cough, hemoptysis, dyspnoea, diarrhea, muscle soreness, dysosmia, lymphopenia and dysgeusia amongst others. The virus mainly infects humans, various other mammals, avian species and some other companion livestock. SARS-CoV-2 cellular entry is primarily accomplished by molecular interaction between the virus's spike (S) protein and the host cell surface receptor, angiotensin-converting enzyme 2 (ACE2), although other host cell-associated receptors/factors, such as neuropilin 1 (NRP-1) and neuropilin 2 (NRP-2), C-type lectin receptors (CLRs), as well as proteases such as TMPRSS2 (transmembrane serine protease 2) and furin, might also play a crucial role in infection, tropism, pathogenesis and clinical outcome. Furthermore, several structural and non-structural proteins of the virus themselves are very critical in determining the clinical outcome following infection. Considering such critical role(s) of the abovementioned host cell receptors, associated proteases/factors and virus structural/non-structural proteins (NSPs), it may be quite prudent to therapeutically target them through a multipronged clinical regimen to combat the disease. Twit Text FOAVip Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34572076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34572076 #FOAvip English Wikipedia <ref>{{Cite pmid|34572076}}</ref> Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets #MMPMID34572076 Chaudhary JK; Yadav R; Chaudhary PK; Maurya A; Roshan R; Azam F; Mehta J; Handu S; Prasad R; Jain N; Pandey AK; Dhamija P Cells 2021[Sep]; 10 (9): ä PMID34572076show ga Coronavirus disease 19 (COVID-19) is caused by an enveloped, positive-sense, single-stranded RNA virus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the realm Riboviria, order Nidovirales, family Coronaviridae, genus Betacoronavirus and the species Severe acute respiratory syndrome-related coronavirus. This viral disease is characterized by a myriad of varying symptoms, such as pyrexia, cough, hemoptysis, dyspnoea, diarrhea, muscle soreness, dysosmia, lymphopenia and dysgeusia amongst others. The virus mainly infects humans, various other mammals, avian species and some other companion livestock. SARS-CoV-2 cellular entry is primarily accomplished by molecular interaction between the virus's spike (S) protein and the host cell surface receptor, angiotensin-converting enzyme 2 (ACE2), although other host cell-associated receptors/factors, such as neuropilin 1 (NRP-1) and neuropilin 2 (NRP-2), C-type lectin receptors (CLRs), as well as proteases such as TMPRSS2 (transmembrane serine protease 2) and furin, might also play a crucial role in infection, tropism, pathogenesis and clinical outcome. Furthermore, several structural and non-structural proteins of the virus themselves are very critical in determining the clinical outcome following infection. Considering such critical role(s) of the abovementioned host cell receptors, associated proteases/factors and virus structural/non-structural proteins (NSPs), it may be quite prudent to therapeutically target them through a multipronged clinical regimen to combat the disease. |*COVID-19/pathology/virology[MESH] |*Host Microbial Interactions[MESH] |Angiotensin-Converting Enzyme 2/chemistry/metabolism[MESH] |Animals[MESH] |Drug Delivery Systems[MESH] |Furin/chemistry/metabolism[MESH] |Humans[MESH] |Lectins, C-Type/chemistry/metabolism[MESH] |Molecular Structure[MESH] |Neuropilins/chemistry/metabolism[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH] |Protein Binding[MESH] |Receptors, Virus/chemistry/metabolism[MESH] |SARS-CoV-2/*pathogenicity[MESH] |Serine Endopeptidases/chemistry/metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH] |Treatment Outcome[MESH] |Viral Nonstructural Proteins/chemistry/metabolism[MESH]Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors a(epmc).pdf DeepDyve Pubget Overpricing