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10.3390/biology10090852 http://scihub22266oqcxt.onion/10.3390/biology10090852 34571729!8469745!34571729     free     free     free       Biology+(Basel) 2021 ; 10 (9): ? Nephropedia Template TP {{tp|p=34571729|t=2021. The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 |pdf=|usr=}}{{34571729}} gab.com Text The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 JO: Biology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34571729 #FOAvip COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a "cytokine storm". In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy. Twit Text FOAVip The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 ????Biology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34571729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34571729 #FOAvip English Wikipedia <ref>{{Cite pmid|34571729}}</ref> The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 #MMPMID34571729 Nechipurenko YD; Semyonov DA; Lavrinenko IA; Lagutkin DA; Generalov EA; Zaitceva AY; Matveeva OV; Yegorov YE Biology (Basel) 2021[Aug]; 10 (9): ? PMID34571729show ga COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a "cytokine storm". In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy. ?The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing