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10.7554/eLife.66709 http://scihub22266oqcxt.onion/10.7554/eLife.66709 34569930!8516418!34569930     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=34569930|t=2021. TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis |pdf=|usr=}}{{34569930}} gab.com Text TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=34569930 #FOAvip Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in central nervous system (CNS) neuron remains unclear. Here, we identify endocytic defects in neuroendocrine cells and neurons from TRPM7 knockout (KO) mice, indicating a role of TRPM7 in synaptic vesicle endocytosis. Our experiments further pinpoint the importance of TRPM7 as an ion channel in synaptic vesicle endocytosis. Ca(2+) imaging detects a defect in presynaptic Ca(2+) dynamics in TRPM7 KO neuron, suggesting an importance of Ca(2+) influx via TRPM7 in synaptic vesicle endocytosis. Moreover, the short-term depression is enhanced in both excitatory and inhibitory synaptic transmissions from TRPM7 KO mice. Taken together, our data suggests that Ca(2+) influx via TRPM7 may be critical for short-term plasticity of synaptic strength by regulating synaptic vesicle endocytosis in neurons. Twit Text FOAVip TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=34569930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34569930 #FOAvip English Wikipedia <ref>{{Cite pmid|34569930}}</ref> TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis #MMPMID34569930 Jiang ZJ; Li W; Yao LH; Saed B; Rao Y; Grewe BS; McGinley A; Varga K; Alford S; Hu YS; Gong LW Elife 2021[Sep]; 10 (ä): ä PMID34569930show ga Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in central nervous system (CNS) neuron remains unclear. Here, we identify endocytic defects in neuroendocrine cells and neurons from TRPM7 knockout (KO) mice, indicating a role of TRPM7 in synaptic vesicle endocytosis. Our experiments further pinpoint the importance of TRPM7 as an ion channel in synaptic vesicle endocytosis. Ca(2+) imaging detects a defect in presynaptic Ca(2+) dynamics in TRPM7 KO neuron, suggesting an importance of Ca(2+) influx via TRPM7 in synaptic vesicle endocytosis. Moreover, the short-term depression is enhanced in both excitatory and inhibitory synaptic transmissions from TRPM7 KO mice. Taken together, our data suggests that Ca(2+) influx via TRPM7 may be critical for short-term plasticity of synaptic strength by regulating synaptic vesicle endocytosis in neurons. |*Endocytosis[MESH] |*Neural Inhibition[MESH] |*Neuronal Plasticity[MESH] |*Synaptic Transmission[MESH] |Animals[MESH] |Calcium Signaling[MESH] |Calcium/metabolism[MESH] |Chromaffin Cells/metabolism[MESH] |Excitatory Postsynaptic Potentials[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Inhibitory Postsynaptic Potentials[MESH] |Kinetics[MESH] |Male[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Neurons/*metabolism[MESH] |Synaptic Vesicles/genetics/*metabolism[MESH]TRPM7 is critical for short-term synaptic depression by regulating syn(epmc).pdf DeepDyve Pubget Overpricing