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10.1177/20587384211048026 http://scihub22266oqcxt.onion/10.1177/20587384211048026 34569339!8477699!34569339     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34569339&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34569339.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Immunopathol+Pharmacol 2021 ; 35 (ä): 20587384211048026 Nephropedia Template TP {{tp|p=34569339|t=2021. A scoping review of the pathophysiology of COVID-19 |pdf=|usr=}}{{34569339}} gab.com Text A scoping review of the pathophysiology of COVID-19 JO: Int J Immunopathol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34569339 #FOAvip COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. While enormous strides have been made in understanding the molecular pathways involved in patients infected with coronaviruses an overarching and comprehensive understanding of the pathogenesis of COVID-19 is lacking. Such an understanding is essential in the formulation of effective prophylactic and treatment strategies. Based on clinical, proteomic, and genomic studies as well as autopsy data severe COVID-19 disease can be considered to be the connection of three basic pathologic processes, namely a pulmonary macrophage activation syndrome with uncontrolled inflammation, a complement-mediated endothelialitis together with a procoagulant state with a thrombotic microangiopathy. In addition, platelet activation with the release of serotonin and the activation and degranulation of mast cells contributes to the hyper-inflammatory state. Auto-antibodies have been demonstrated in a large number of hospitalized patients which adds to the end-organ damage and pro-thrombotic state. This paper provides a clinical overview of the major pathogenetic mechanism leading to severe COVID-19 disease. Twit Text FOAVip A scoping review of the pathophysiology of COVID-19 ????Int J Immunopathol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34569339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34569339 #FOAvip English Wikipedia <ref>{{Cite pmid|34569339}}</ref> A scoping review of the pathophysiology of COVID-19 #MMPMID34569339 Marik PE; Iglesias J; Varon J; Kory P Int J Immunopathol Pharmacol 2021[Jan]; 35 (ä): 20587384211048026 PMID34569339show ga COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. While enormous strides have been made in understanding the molecular pathways involved in patients infected with coronaviruses an overarching and comprehensive understanding of the pathogenesis of COVID-19 is lacking. Such an understanding is essential in the formulation of effective prophylactic and treatment strategies. Based on clinical, proteomic, and genomic studies as well as autopsy data severe COVID-19 disease can be considered to be the connection of three basic pathologic processes, namely a pulmonary macrophage activation syndrome with uncontrolled inflammation, a complement-mediated endothelialitis together with a procoagulant state with a thrombotic microangiopathy. In addition, platelet activation with the release of serotonin and the activation and degranulation of mast cells contributes to the hyper-inflammatory state. Auto-antibodies have been demonstrated in a large number of hospitalized patients which adds to the end-organ damage and pro-thrombotic state. This paper provides a clinical overview of the major pathogenetic mechanism leading to severe COVID-19 disease. |COVID-19/blood/immunology/physiopathology/*virology[MESH] |Complement Activation[MESH] |Complement System Proteins/metabolism[MESH] |Cytokines/blood[MESH] |Disease Progression[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Inflammation Mediators/blood[MESH] |Inflammation/blood/immunology/physiopathology/virology[MESH] |Macrophage Activation Syndrome/blood/immunology/physiopathology/virology[MESH] |Platelet Activation[MESH] |SARS-CoV-2/immunology/*pathogenicity[MESH] |Serotonin/blood[MESH] |Severity of Illness Index[MESH]A scoping review of the pathophysiology of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing