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10.1111/imm.13420 http://scihub22266oqcxt.onion/10.1111/imm.13420 34558663!ä!34558663 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2022 ; 165 (1): 3-21 Nephropedia Template TP {{tp|p=34558663|t=2022. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases |pdf=|usr=}}{{34558663}} gab.com Text Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34558663 #FOAvip An autoimmune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self-antigens. It often leads to structural and functional damage to organs and systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Hence, there is an urgent need for new treatment targets. TRPM7 is an enzyme-coupled, transient receptor ion channel of the subfamily M that plays a vital role in pathologic and physiologic conditions. While TRPM7 is constitutively activated under certain conditions, it can regulate cell migration, polarization, proliferation and cytokine secretion. However, a growing body of evidence highlights the critical role of TRPM7 in autoimmune diseases, including rheumatoid arthritis, multiple sclerosis and diabetes. Herein, we present (a) a review of the channel kinase properties of TRPM7 and its pharmacological properties, (b) discuss the role of TRPM7 in immune cells (neutrophils, macrophages, lymphocytes and mast cells) and its upstream immunoreactive substances, and (c) highlight TRPM7 as a potential therapeutic target for autoimmune diseases. Twit Text FOAVip Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34558663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34558663 #FOAvip English Wikipedia <ref>{{Cite pmid|34558663}}</ref> Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases #MMPMID34558663 Liang HY; Chen Y; Wei X; Ma GG; Ding J; Lu C; Zhou RP; Hu W Immunology 2022[Jan]; 165 (1): 3-21 PMID34558663show ga An autoimmune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self-antigens. It often leads to structural and functional damage to organs and systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Hence, there is an urgent need for new treatment targets. TRPM7 is an enzyme-coupled, transient receptor ion channel of the subfamily M that plays a vital role in pathologic and physiologic conditions. While TRPM7 is constitutively activated under certain conditions, it can regulate cell migration, polarization, proliferation and cytokine secretion. However, a growing body of evidence highlights the critical role of TRPM7 in autoimmune diseases, including rheumatoid arthritis, multiple sclerosis and diabetes. Herein, we present (a) a review of the channel kinase properties of TRPM7 and its pharmacological properties, (b) discuss the role of TRPM7 in immune cells (neutrophils, macrophages, lymphocytes and mast cells) and its upstream immunoreactive substances, and (c) highlight TRPM7 as a potential therapeutic target for autoimmune diseases. |*Autoimmunity[MESH] |*Immunomodulation/drug effects[MESH] |Animals[MESH] |Autoimmune Diseases/diagnosis/*etiology/*metabolism/therapy[MESH] |Biomarkers[MESH] |Disease Susceptibility[MESH] |Drug Development[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |Immune System/cytology/drug effects/immunology/metabolism[MESH] |Ion Channel Gating/drug effects[MESH] |Organ Specificity/drug effects/genetics/immunology[MESH] |Protein Kinase Inhibitors/chemistry/pharmacology[MESH] |Protein Serine-Threonine Kinases/chemistry/*genetics/*metabolism[MESH] |Signal Transduction/drug effects[MESH] |Structure-Activity Relationship[MESH]Immunomodulatory functions of TRPM7 and its implications in autoimmune(epmc).pdf DeepDyve Pubget Overpricing