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10.1038/s41598-021-98289-x http://scihub22266oqcxt.onion/10.1038/s41598-021-98289-x 34556735!8460804!34556735     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 18985 Nephropedia Template TP {{tp|p=34556735|t=2021. Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates |pdf=|usr=}}{{34556735}} gab.com Text Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34556735 #FOAvip The COVID-19 pandemic is raging. It revealed the importance of rapid scientific advancement towards understanding and treating new diseases. To address this challenge, we adapt an explainable artificial intelligence algorithm for data fusion and utilize it on new omics data on viral-host interactions, human protein interactions, and drugs to better understand SARS-CoV-2 infection mechanisms and predict new drug-target interactions for COVID-19. We discover that in the human interactome, the human proteins targeted by SARS-CoV-2 proteins and the genes that are differentially expressed after the infection have common neighbors central in the interactome that may be key to the disease mechanisms. We uncover 185 new drug-target interactions targeting 49 of these key genes and suggest re-purposing of 149 FDA-approved drugs, including drugs targeting VEGF and nitric oxide signaling, whose pathways coincide with the observed COVID-19 symptoms. Our integrative methodology is universal and can enable insight into this and other serious diseases. Twit Text FOAVip Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34556735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34556735 #FOAvip English Wikipedia <ref>{{Cite pmid|34556735}}</ref> Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates #MMPMID34556735 Zambrana C; Xenos A; Bottcher R; Malod-Dognin N; Przulj N Sci Rep 2021[Sep]; 11 (1): 18985 PMID34556735show ga The COVID-19 pandemic is raging. It revealed the importance of rapid scientific advancement towards understanding and treating new diseases. To address this challenge, we adapt an explainable artificial intelligence algorithm for data fusion and utilize it on new omics data on viral-host interactions, human protein interactions, and drugs to better understand SARS-CoV-2 infection mechanisms and predict new drug-target interactions for COVID-19. We discover that in the human interactome, the human proteins targeted by SARS-CoV-2 proteins and the genes that are differentially expressed after the infection have common neighbors central in the interactome that may be key to the disease mechanisms. We uncover 185 new drug-target interactions targeting 49 of these key genes and suggest re-purposing of 149 FDA-approved drugs, including drugs targeting VEGF and nitric oxide signaling, whose pathways coincide with the observed COVID-19 symptoms. Our integrative methodology is universal and can enable insight into this and other serious diseases. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/therapeutic use[MESH] |Artificial Intelligence[MESH] |COVID-19/genetics/metabolism[MESH] |Drug Evaluation, Preclinical/*methods[MESH] |Drug Repositioning/methods[MESH] |Gene Regulatory Networks/genetics[MESH] |Humans[MESH] |Models, Theoretical[MESH] |Pandemics[MESH] |Pharmaceutical Preparations[MESH] |SARS-CoV-2/drug effects/*genetics/pathogenicity[MESH]Network neighbors of viral targets and differentially expressed genes (epmc).pdf DeepDyve Pubget Overpricing