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10.1038/s42003-021-02663-4 http://scihub22266oqcxt.onion/10.1038/s42003-021-02663-4 34552191!8458489!34552191     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 1134 Nephropedia Template TP {{tp|p=34552191|t=2021. Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts |pdf=|usr=}}{{34552191}} gab.com Text Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34552191 #FOAvip The ability to predict emerging variants of SARS-CoV-2 would be of enormous value, as it would enable proactive design of vaccines in advance of such emergence. We estimated diversity of each site on a multiple sequence alignment (MSA) of the Spike (S) proteins from close relatives of SARS-CoV-2 that infected bat and pangolin before the pandemic. Then we compared the locations of high diversity sites in this MSA and those of mutations found in multiple emerging lineages of human-infecting SARS-CoV-2. This comparison revealed a significant correspondence, which suggests that a limited number of sites in this protein are repeatedly substituted in different lineages of this group of viruses. It follows, therefore, that the sites of future emerging mutations in SARS-CoV-2 can be predicted by analyzing their relatives (outgroups) that have infected non-human hosts. We discuss a possible evolutionary basis for these substitutions and provide a list of frequently substituted sites that potentially include future emerging variants in SARS-CoV-2. Twit Text FOAVip Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34552191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34552191 #FOAvip English Wikipedia <ref>{{Cite pmid|34552191}}</ref> Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts #MMPMID34552191 Katoh K; Standley DM Commun Biol 2021[Sep]; 4 (1): 1134 PMID34552191show ga The ability to predict emerging variants of SARS-CoV-2 would be of enormous value, as it would enable proactive design of vaccines in advance of such emergence. We estimated diversity of each site on a multiple sequence alignment (MSA) of the Spike (S) proteins from close relatives of SARS-CoV-2 that infected bat and pangolin before the pandemic. Then we compared the locations of high diversity sites in this MSA and those of mutations found in multiple emerging lineages of human-infecting SARS-CoV-2. This comparison revealed a significant correspondence, which suggests that a limited number of sites in this protein are repeatedly substituted in different lineages of this group of viruses. It follows, therefore, that the sites of future emerging mutations in SARS-CoV-2 can be predicted by analyzing their relatives (outgroups) that have infected non-human hosts. We discuss a possible evolutionary basis for these substitutions and provide a list of frequently substituted sites that potentially include future emerging variants in SARS-CoV-2. |*Evolution, Molecular[MESH] |Animals[MESH] |Genome, Viral/genetics[MESH] |SARS-CoV-2/*genetics[MESH]Emerging SARS-CoV-2 variants follow a historical pattern recorded in o(epmc).pdf DeepDyve Pubget Overpricing