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10.30802/AALAS-CM-20-000119

http://scihub22266oqcxt.onion/10.30802/AALAS-CM-20-000119
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suck abstract from ncbi


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pmid34548126      Comp+Med 2021 ; 71 (5): 411-432
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  • Overview of Nonhuman Primate Models of SARS-CoV-2 Infection #MMPMID34548126
  • Trichel AM
  • Comp Med 2021[Oct]; 71 (5): 411-432 PMID34548126show ga
  • COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models have been used to identify effective therapies and vaccines. Current animal models do not express the full spectrum of human COVID-19 disease and pathology, with most exhibiting mild to moderate disease without mortality. NHPs are physiologically, genetically, and immunologically more closely related to humans than other animal species; thus, they provide a relevant model for SARS-CoV-2 investigations. This overview summarizes NHP models of SARS-CoV-2 and their role in vaccine and therapeutic development.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Animals[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]


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