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10.1093/infdis/jiab482

http://scihub22266oqcxt.onion/10.1093/infdis/jiab482
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34543421!8499975!34543421
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suck abstract from ncbi


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pmid34543421      J+Infect+Dis 2021 ; 224 (10): 1707-1711
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  • Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins manufactured from Post-COVID-19 and COVID-19-Vaccinated Plasma Donations #MMPMID34543421
  • Karbiener M; Farcet MR; Schwaiger J; Powers N; Lenart J; Stewart JM; Tallman H; Kreil TR
  • J Infect Dis 2021[Nov]; 224 (10): 1707-1711 PMID34543421show ga
  • From September 2020, some immunoglobulin lots from US plasma contained neutralizing antibodies against the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Paralleled by the increasing numbers of post-coronavirus disease 2019 (COVID-19) donors, immunoglobulin lot antibody positivity increased to 93% by January 2021, at a mean titer of approximately 30 IU/mL. The correlation predicted that anti-SARS-CoV-2 potency would reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of plasma donors vaccinated against COVID-19 resulted in a mean antibody titer of >600 IU/mL in July 2021 immunoglobulin lots, with SARS-CoV-2 antibody titers for several lots even higher than those of earlier produced hyperimmune globulin products.
  • |*COVID-19/therapy[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Neutralizing[MESH]
  • |Antibodies, Viral[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]


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