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10.18502/ijm.v13i2.5973 http://scihub22266oqcxt.onion/10.18502/ijm.v13i2.5973 34540148!8408024!34540148     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Iran+J+Microbiol 2021 ; 13 (2): 145-155 Nephropedia Template TP {{tp|p=34540148|t=2021. Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia |pdf=|usr=}}{{34540148}} gab.com Text Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia JO: Iran J Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34540148 #FOAvip BACKGROUND AND OBJECTIVES: In first May 2020, Indonesia has been successfully submitted the first three full-length sequence of SARS-CoV-2 to GISAID database. Until September 10(th), 2020, Indonesia had submitted 54 WGS. In this study, we have analyzed and annotated SARS-CoV-2 mutations in spike protein and main proteases. MATERIALS AND METHODS: The Whole Genome Sequence (WGS) of Indonesia were obtained from GISAID data base. The 54 data were taken from March to September 10(th), 2020. The sequences corresponded to Spike Protein (SP), 3-chymotrypsin like protease (3CLpro), and papain like protease (PLpro) were selected. The Wuhan genome was used as reference. RESULTS: In total WGS from Indonesia, we found 5 major clades, which dominated as G clade, where the mutation of D614G was found. This D614G was identified as much as 59%, which mostly reported in late samples submitted. Beside D614G mutation, we report three unique mutations: A352S, S477I, and Q677H. Besides, some mutations were also detected in two domains that were expected to be conserved region, the main viral proteases: PLpro (P77L and V205I), 3CLpro (M49I and L50F). CONCLUSION: The analysis of SARS-CoV-2 from WGS Indonesia showed a high genetic variation. The diversity in SARS-CoV-2 may epidemiologically enhance virulence and transmission of this virus. The prevalence of D614G over the time in different locations, indicating that changes in this mutation may related to host infection and the viral transmission. However, some mutations that have been reported in this study were not eligible for the most stable conformation. Twit Text FOAVip Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia ????Iran J Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34540148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34540148 #FOAvip English Wikipedia <ref>{{Cite pmid|34540148}}</ref> Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia #MMPMID34540148 Ulfah M; Helianti I Iran J Microbiol 2021[Apr]; 13 (2): 145-155 PMID34540148show ga BACKGROUND AND OBJECTIVES: In first May 2020, Indonesia has been successfully submitted the first three full-length sequence of SARS-CoV-2 to GISAID database. Until September 10(th), 2020, Indonesia had submitted 54 WGS. In this study, we have analyzed and annotated SARS-CoV-2 mutations in spike protein and main proteases. MATERIALS AND METHODS: The Whole Genome Sequence (WGS) of Indonesia were obtained from GISAID data base. The 54 data were taken from March to September 10(th), 2020. The sequences corresponded to Spike Protein (SP), 3-chymotrypsin like protease (3CLpro), and papain like protease (PLpro) were selected. The Wuhan genome was used as reference. RESULTS: In total WGS from Indonesia, we found 5 major clades, which dominated as G clade, where the mutation of D614G was found. This D614G was identified as much as 59%, which mostly reported in late samples submitted. Beside D614G mutation, we report three unique mutations: A352S, S477I, and Q677H. Besides, some mutations were also detected in two domains that were expected to be conserved region, the main viral proteases: PLpro (P77L and V205I), 3CLpro (M49I and L50F). CONCLUSION: The analysis of SARS-CoV-2 from WGS Indonesia showed a high genetic variation. The diversity in SARS-CoV-2 may epidemiologically enhance virulence and transmission of this virus. The prevalence of D614G over the time in different locations, indicating that changes in this mutation may related to host infection and the viral transmission. However, some mutations that have been reported in this study were not eligible for the most stable conformation. äBioinformatic analysis of the whole genome sequences of SARS-CoV-2 fro(epmc).pdf DeepDyve Pubget Overpricing