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10.2147/IJGM.S329810 http://scihub22266oqcxt.onion/10.2147/IJGM.S329810 34539185!8445096!34539185     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34539185&cmd=llinks): Failed to open stream: HTTP request failed! 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Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID) |pdf=|usr=}}{{34539185}} gab.com Text Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID) JO: Int J Gen Med http://www.kidney.de/pget.php?&tw=1&pmid=34539185 #FOAvip BACKGROUND: Colchicine has been proposed as a potential therapy in coronavirus disease 2019 (COVID-19) due to their anti-inflammatory actions. METHODS: The COL-COVID study was a prospective, randomized, controlled and open-label clinical trial that compared colchicine added to standard treatment vs standard treatment in hospitalized COVID-19 patients that do not need mechanical ventilatory support. Colchicine was initiated within the first 48 hours of admission at a 1.5 mg loading dose, followed by 0.5 mg b.i.d. for one week and 0.5 mg per day for 28 days. The study endpoints were clinical status (7-points WHO ordinal scale) and inflammatory biomarkers (IL-6 and CRP). RESULTS: A total of 103 patients (51+/-12 years, 52% male) were randomly allocated to colchicine arm (n=52) and control arm (n=51). At day 28, all patients in the colchicine group were alive and discharged, whereas in the control group, two patients died in-hospital and one patient remained hospitalized. Clinical improvement in terms of changes on WHO scale at day 14 and 28 and time to 1-point clinical improvement did not differ between the two groups. Clinical deterioration (increase of at least 1-point in WHO scale) was observed in a higher proportion of cases in colchicine group (13.8%) vs control group (5.8%) (p=0.303); after adjustment by baseline risk factors and concomitant therapies, colchicine therapy was associated with a lower risk of clinical deterioration (p=0.030). Inflammatory biomarkers CRP and IL-6 concentrations course did not differ between the two arms. CONCLUSION: In hospitalized COVID-19 patients, colchicine treatment neither improved the clinical status, nor the inflammatory response, over the standard treatment. Nevertheless, a preventive effect for further clinical deterioration might be possible. TRIAL REGISTRATION: NCT04350320. Twit Text FOAVip Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID) ????Int J Gen Med http://www.kidney.de/pget.php?&tw=1&pmid=34539185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34539185 #FOAvip English Wikipedia <ref>{{Cite pmid|34539185}}</ref> Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID) #MMPMID34539185 Pascual-Figal DA; Roura-Piloto AE; Moral-Escudero E; Bernal E; Albendin-Iglesias H; Perez-Martinez MT; Noguera-Velasco JA; Cebreiros-Lopez I; Hernandez-Vicente A; Vazquez-Andres D; Sanchez-Perez C; Khan A; Sanchez-Cabo F; Garcia-Vazquez E Int J Gen Med 2021[]; 14 (ä): 5517-5526 PMID34539185show ga BACKGROUND: Colchicine has been proposed as a potential therapy in coronavirus disease 2019 (COVID-19) due to their anti-inflammatory actions. METHODS: The COL-COVID study was a prospective, randomized, controlled and open-label clinical trial that compared colchicine added to standard treatment vs standard treatment in hospitalized COVID-19 patients that do not need mechanical ventilatory support. Colchicine was initiated within the first 48 hours of admission at a 1.5 mg loading dose, followed by 0.5 mg b.i.d. for one week and 0.5 mg per day for 28 days. The study endpoints were clinical status (7-points WHO ordinal scale) and inflammatory biomarkers (IL-6 and CRP). RESULTS: A total of 103 patients (51+/-12 years, 52% male) were randomly allocated to colchicine arm (n=52) and control arm (n=51). At day 28, all patients in the colchicine group were alive and discharged, whereas in the control group, two patients died in-hospital and one patient remained hospitalized. Clinical improvement in terms of changes on WHO scale at day 14 and 28 and time to 1-point clinical improvement did not differ between the two groups. Clinical deterioration (increase of at least 1-point in WHO scale) was observed in a higher proportion of cases in colchicine group (13.8%) vs control group (5.8%) (p=0.303); after adjustment by baseline risk factors and concomitant therapies, colchicine therapy was associated with a lower risk of clinical deterioration (p=0.030). Inflammatory biomarkers CRP and IL-6 concentrations course did not differ between the two arms. CONCLUSION: In hospitalized COVID-19 patients, colchicine treatment neither improved the clinical status, nor the inflammatory response, over the standard treatment. Nevertheless, a preventive effect for further clinical deterioration might be possible. TRIAL REGISTRATION: NCT04350320. äColchicine in Recently Hospitalized Patients with COVID-19: A Randomiz(epmc).pdf DeepDyve Pubget Overpricing