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10.1016/j.jmb.2021.167249 http://scihub22266oqcxt.onion/10.1016/j.jmb.2021.167249 34537233!8444475!34537233     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2022 ; 434 (4): 167249 Nephropedia Template TP {{tp|p=34537233|t=2022. PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field |pdf=|usr=}}{{34537233}} gab.com Text PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34537233 #FOAvip In the past decade, emerging viral outbreaks like SARS-CoV-2, Zika and Ebola have presented major challenges to the global health system. Viruses are unique pathogens in that they fully rely on the host cell to complete their lifecycle and potentiate disease. Therefore, programmed cell death (PCD), a key component of the host innate immune response, is an effective strategy for the host cell to curb viral spread. The most well-established PCD pathways, pyroptosis, apoptosis and necroptosis, can be activated in response to viruses. Recently, extensive crosstalk between PCD pathways has been identified, and there is evidence that molecules from all three PCD pathways can be activated during virus infection. These findings have led to the emergence of the concept of PANoptosis, defined as an inflammatory PCD pathway regulated by the PANoptosome complex with key features of pyroptosis, apoptosis, and/or necroptosis that cannot be accounted for by any of these three PCD pathways alone. While PCD is important to eliminate infected cells, many viruses are equipped to hijack host PCD pathways to benefit their own propagation and subvert host defense, and PCD can also lead to the production of inflammatory cytokines and inflammation. Therefore, PANoptosis induced by viral infection contributes to either host defense or viral pathogenesis in context-specific ways. In this review, we will discuss the multi-faceted roles of PCD pathways in controlling viral infections. Twit Text FOAVip PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34537233 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34537233 #FOAvip English Wikipedia <ref>{{Cite pmid|34537233}}</ref> PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field #MMPMID34537233 Nguyen LN; Kanneganti TD J Mol Biol 2022[Feb]; 434 (4): 167249 PMID34537233show ga In the past decade, emerging viral outbreaks like SARS-CoV-2, Zika and Ebola have presented major challenges to the global health system. Viruses are unique pathogens in that they fully rely on the host cell to complete their lifecycle and potentiate disease. Therefore, programmed cell death (PCD), a key component of the host innate immune response, is an effective strategy for the host cell to curb viral spread. The most well-established PCD pathways, pyroptosis, apoptosis and necroptosis, can be activated in response to viruses. Recently, extensive crosstalk between PCD pathways has been identified, and there is evidence that molecules from all three PCD pathways can be activated during virus infection. These findings have led to the emergence of the concept of PANoptosis, defined as an inflammatory PCD pathway regulated by the PANoptosome complex with key features of pyroptosis, apoptosis, and/or necroptosis that cannot be accounted for by any of these three PCD pathways alone. While PCD is important to eliminate infected cells, many viruses are equipped to hijack host PCD pathways to benefit their own propagation and subvert host defense, and PCD can also lead to the production of inflammatory cytokines and inflammation. Therefore, PANoptosis induced by viral infection contributes to either host defense or viral pathogenesis in context-specific ways. In this review, we will discuss the multi-faceted roles of PCD pathways in controlling viral infections. |*Apoptosis[MESH] |Animals[MESH] |Humans[MESH] |Models, Biological[MESH] |Necroptosis[MESH] |Pyroptosis[MESH]PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell De(epmc).pdf DeepDyve Pubget Overpricing